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home » Transcription Regulators » HIF Antibody / HIF Antibodies » HIF-3α (D-16): sc-8717

HIF-3α (D-16) Antibody: sc-8717

  |  Datasheet
  • goat polyclonal IgG, 200 µg/ml
  • epitope mapping at the N-terminus of HIF-3α of mouse origin
  • recommended for detection of HIF-3α of mouse and rat and, to a lesser extent, human origin by WB, IF and ELISA
  • blocking peptide, sc-8717 P
  • TransCruz reagent for Gel Supershift and ChIP applications, sc-8717 X, 200 µg/0.1 ml
 
Additional HIF Antibodies ...
 
Ordering Information
Recommended Support Products:
(click button of application of choice)
WB   IF   Gel Shift   ChIP   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Mouse Hif3a 53417 7 A2 Q0VBL6
 N/A
 
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
HIF-3α (D-16) sc-8717 200 µg/ml $279
HIF-3α (D-16) P sc-8717 P
(peptide)
 100 µg/0.5 ml $61
HIF-3α (D-16) X sc-8717 X 200 µg/0.1 ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
HIF-3α siRNA (m) sc-38168 10 µM $258
HIF-3α (m)-PR sc-38168-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
HIF-3α shRNA Plasmid (m) sc-38168-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
HIF-3α shRNA (m) Lentiviral Particles sc-38168-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
mouse liver extract sc-2256 500 µg/200 µl $104
rat liver extract sc-2395 500 µg/200 µl $104

HIF-3α Background Information
Cell growth and viability is compromised by oxygen deprivation (hypoxia). Hypoxia-inducible factors, including HIF-1å, HIF-1∫ (also designated Arnt 1), EPAS-1 (also designated HIF-2å) and HIF-3å, induce glycolysis, erythropoiesis and angiogenesis in order to restore oxygen homeostasis. Hypoxia-inducible factors are members of the Per-Arnt-Sim (PAS) domain transcription factor family. In response to hypoxia, HIF-1å is upregulated and forms a heterodimer with Arnt 1 to form the HIF-1 complex. The HIF-1 complex recognizes and binds to the hypoxia responsive element (HRE) of hypoxia-inducible genes, thereby activating transcription. Hypoxia-inducible expression of some genes such as Glut-1, p53, p21 or Bcl-2, is HIF-1å dependent, whereas expression of others, such as p27, GADD 153 or HO-1, is HIF-1å independent. EPAS-1 and HIF-3å have also been shown to form heterodimeric complexes with Arnt 1 in response to hypoxia.
HIF-3α (D-16)
Click on image to enlarge
sc-8717
HIF-3α (D-16): sc-8717. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.
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