santa cruz biotechnology, inc.
SCBT Logo

Welcome!        Items in Cart     Quick Order
home » Transcription Regulators » HIF Antibody / HIF Antibodies » HIF-1α (C-19): sc-8711

HIF-1α (C-19) Antibody: sc-8711

  |  Datasheet
  • goat polyclonal IgG, 200 µg/ml
  • epitope mapping near the C-terminus of HIF-1α of human origin
  • recommended for detection of HIF-1α of mouse, rat, human and Xenopus origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
  • blocking peptide, sc-8711 P
  • TransCruz reagent for Gel Supershift and ChIP applications, sc-8711 X, 200 µg/0.1 ml
 
Additional HIF Antibodies ...
 
Ordering InformationProduct Citations
Recommended Support Products:
(click button of application of choice)
WB   IF   Gel Shift   ChIP   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human HIF1A 3091 14q23.2 NM_001530, NM_181054 Q16665
 603348
Mouse Hif1a 15251 12 C3 Q61221
 N/A
 
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
HIF-1α (C-19) sc-8711 200 µg/ml $279
HIF-1α (C-19) P sc-8711 P
(peptide)
 100 µg/0.5 ml $61
HIF-1α (C-19) X sc-8711 X 200 µg/0.1 ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
HIF-1α siRNA (h) sc-35561 10 µM $258
HIF-1α siRNA (m) sc-35562 10 µM $258
HIF-1α siRNA (h2) sc-44225 10 µM $258
HIF-1α (h)-PR sc-35561-PR 10 µM $23
HIF-1α (m)-PR sc-35562-PR 10 µM $23
HIF-1α (h2)-PR sc-44225-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
HIF-1α shRNA Plasmid (h) sc-35561-SH 20 µg $520
HIF-1α shRNA Plasmid (m) sc-35562-SH 20 µg $520
HIF-1α shRNA Plasmid (h2) sc-44225-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
HIF-1α shRNA (h) Lentiviral Particles sc-35561-V 200 µl $625
HIF-1α shRNA (m) Lentiviral Particles sc-35562-V 200 µl $625
HIF-1α shRNA (h2) Lentiviral Particles sc-44225-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
K-562 Whole Cell Lysate sc-2203 500 µg/200 µl $104
HeLa + CoCl2 Cell Lysate sc-24679 500 µg/200 µl $104

HIF-1α Background Information
Cell growth and viability is compromised by oxygen deprivation (hypoxia). Hypoxia-inducible factors, including HIF-1å, HIF-1∫ (also designated Arnt 1), EPAS-1 (also designated HIF-2å) and HIF-3å, induce glycolysis, erythropoiesis and angiogenesis in order to restore oxygen homeostasis. Hypoxia-inducible factors are members of the Per-Arnt-Sim (PAS) domain transcription factor family. In response to hypoxia, HIF-1å is upregulated and forms a heterodimer with Arnt 1 to form the HIF-1 complex. The HIF-1 complex recognizes and binds to the hypoxia responsive element (HRE) of hypoxia-inducible genes, thereby activating transcription. Hypoxia-inducible expression of some genes such as Glut-1, p53, p21 or Bcl-2, is HIF-1å dependent, whereas expression of others, such as p27, GADD 153 or HO-1, is HIF-1å independent. EPAS-1 and HIF-3å have also been shown to form heterodimeric complexes with Arnt 1 in response to hypoxia.

HIF-1α (C-19) Product Citations
See how others have used HIF-1α (C-19): sc-8711 antibody and or HIF-1α (C-19) antibody conjugates.


18 total citations
Loading citations.