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home » Transcription Regulators » Evi-1 Antibody / Evi-1 Antibodies » Evi-1 (N-20): sc-8706

Evi-1 (N-20) Antibody: sc-8706

  |  Datasheet
  • goat polyclonal IgG, 200 µg/ml
  • epitope mapping at the N-terminus of Evi-1 of human origin
  • recommended for detection of Evi-1 of human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
  • blocking peptide, sc-8706 P
  • TransCruz reagent for Gel Supershift and ChIP applications, sc-8706 X, 200 µg/0.1 ml
 
Additional Evi-1 Antibodies ...
 
Ordering Information
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   Gel Shift   ChIP   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human EVI1 2122 3q26.2 NM_005241 Q03112
 n/a
Mouse Evi1 14013 3 A3 P14404
 N/A
 
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
Evi-1 (N-20) sc-8706 200 µg/ml $279
Evi-1 (N-20) P sc-8706 P
(peptide)
 100 µg/0.5 ml $61
Evi-1 (N-20) X sc-8706 X 200 µg/0.1 ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Evi-1 siRNA (h) sc-37873 10 µM $258
Evi-1 (h)-PR sc-37873-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Evi-1 shRNA Plasmid (h) sc-37873-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Evi-1 shRNA (h) Lentiviral Particles sc-37873-V 200 µl $625

Evi-1 Background Information
The Evi-1 proto-oncogene contains two zinc finger domains, the second of which is essential for transactivation of the c-Fos promoter and for AP-1 activation. The first zinc finger domain binds to Smad3, suppressing its activity and inhibiting TGF∫ signaling. The t(3;21) (q26;q22) chromosomal translocation produces a chimeric transcription factor, AML-1/Evi-1, that appears to suppress the transactivation of AML-1, which is a stimulator of myeloid cell differentiation. Inappropriate Evi-1 gene expression in hemato-poietic cells has been shown to be associated with acute myelogenous leukemia (AML) and myelodysplastic syndromes.

Evi-1 (N-20)
Click on image to enlarge
sc-8706
Evi-1 (N-20): sc-8706. Western blot analysis of Evi-1 expression in Hep G2 whole cell lysate.
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Datasheets
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