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- rabbit polyclonal IgG, 200 µg/ml
- epitope mapping at the C-terminus of Cdc42 of human origin
- recommended for detection of Cdc42 and Rac1 of mouse, rat, human, Xenopus and Drosophila origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
- blocking peptide, sc-87 P
- agarose conjugate for IP studies, sc-87 AC, 500 µg/0.25 ml agarose
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Cdc42 Background Information
The superfamily of GTP-binding proteins, for which the Ras proteins are prototypes, has been implicated in regulation of diverse biological activities involving various aspects of cell growth and division. One mammalian member of the family, Cdc42, has an amino acid sequence that is similar to those of various members of the Ras superfamily proteins, including N-, K- and H-Ras, Rho proteins and the Rac proteins. On the basis of in vitro phosphorylation studies, it has been suggested that human Cdc42 may function in the signaling pathway of the EGF receptor or related growth factor receptor protein kinases. The Dbl oncogene has been shown to specifically catalyze dissociation of GDP from human Cdc42.
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See how others have used Cdc42 (P1): sc-87 antibody and or Cdc42 (P1) antibody conjugates.
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Cdc42 (P1)
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Cdc42 (P1): sc-87. Western blot analysis of Cdc42 expression in Jurkat (A), 3611-RF (B), HeLa (C) and NIH/3T3 (D) whole cell lysates.
Cdc42 siRNA (m): sc-29257. Western blot analysis of Cdc42 expression in non-transfected control (A) and Cdc42 siRNA transfected (B) NIH/3T3 cells. Blot probed with Cdc42 (P1): sc-87. GAPDH (FL-335): sc-25778 used as specificity and loading control. Cdc42 (P1): sc-87. Western blot analysis of Cdc42 expression in non-transfected 293T: sc-117752 (A), human Cdc42 transfected 293T: sc-110467 (B) and Jurkat (C) whole cell lysates. Cdc42 (P1): sc-87. Western blot analysis of Cdc42 expression in non-transfected 293T: sc-117752 (A), mouse Cdc42 transfected 293T: sc-125122 (B) and Jurkat (C) whole cell lysates. Cdc42 (P1): sc-87. Immunofluorescence staining of methanol-fixed HeLa cells showing membrane and cell projection localization.
Cdc42 (P1): sc-87. Immunoperoxidase staining of formalin fixed, paraffin-embedded human pancreas tissue showing cytoplasmic staining of glandular cells.
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