epitope mapping near the N-terminus of TCF-4 of human origin
recommended for detection of TCF-4 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including bovine, porcine and avian
blocking peptide, sc-8631 P
TransCruz reagent for Gel Supershift and ChIP applications, sc-8631 X, 200 µg/0.1 ml
TCF-4 Background Information T cell factors (TCFs) comprise a family of DNA-binding transcriptional activators that are essential for lymphoid cell development. These transcription factors are activated by the Wnt-1 and Wingless pathways and are characterized by the presence of a conserved protein motif, the high mobility group (HMG) 1 box, which mediates DNA binding. TCF-4 mainly localizes in the cytoplasm and is transported into the nucleus directly bound to ∫-catenin in a cooperative manner. This TCF-4/∫-catenin complex induces expression of Wnt target genes, including multiple cancer-associated genes. c-Jun also interacts with TCF-4 and ∫-catenin, and the phosphorylation-dependent interaction between c-Jun and TCF4 regulates intestinal tumorigenesis by integrating JNK and APC/∫-catenin. TCF-4 is also implicated in bipolar affective disorder.
TCF-4 (N-20) Product Citations
See how others have used TCF-4 (N-20): sc-8631 antibody and or TCF-4 (N-20) antibody conjugates.
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TCF-4 (N-20)
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TCF-4 (N-20): sc-8631. Western blot analysis of TCF-4 expression in non-transfected: sc-117752 (A) and human TCF-4 transfected: sc-115204 (B) 293T whole cell lysates.
TCF-4 (N-20): sc-8631. Immunofluorescence staining of methanol-fixed SW480 cells showing nuclear and cytoplasmic localization.
