p130 Cas/Sin (N-17) Antibody: sc-859

p130 Cas/Sin Background Information
A protein designated p130 Cas (for Crk-associated substrate), represents one of several known substrates for v-Crk encoded p47. p130 Cas (also designated breast cancer anti-estrogen resistance protein 1 or Cas scaffolding protein family member 1), exhibits a high level of tyrosine phosphorylation and is tightly associated with v-Crk, suggesting a role in v-Crk-mediated cell signaling. p130 Cas is a novel SH3-containing signaling molecule with a cluster of multiple putative SH2-binding motifs for v-Crk. Two p130 Cas related proteins, designated Sin (Src interacting or signal integrating protein, also designated Cas3 or HEFS) and Cas-L (human enhancer of filamentatin 1, HEF1 or Cas3), have also been identified. Sin contains SH2/SH3 domains and has been shown to activate Src. Cas-L contains an SH3 domain and has been shown to be a docking protein that serves as a substrate for phosphorylation by several oncogenic tyrosine kinases.