epitope corresponding to amino acids 3-484 mapping within the N-terminal two-thirds of Bcl-6 of human origin
recommended for detection of Bcl-6 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
TransCruz reagent for Gel Supershift and ChIP applications, sc-858 X, 200 µg/0.1 ml
Bcl-6 Background Information Bcl-6, a transcriptional repressor, binds Stat recognition-like DNA elements and influences germinal center development and Th1/Th2 differentiation. Bcl-6 negatively regulates NFkB expression, thereby inhibiting NFkB-mediated cellular functions. HDAC- and silent information regulator (SIR)-2-dependent acet-ylation of Bcl-6 causes downregulation of activity by inhibiting the ability of Bcl-6 to recruit complexes containing histone deacetylases (HDACs). Bcl-6 is frequently deregulated in non-Hodgkin’s B cell lymphomas. The human BCL6 gene has been shown to encode a protein of 706 amino acids.
Bcl-6 (N-3) Product Citations
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Bcl-6 (N-3)
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Bcl-6 (N-3): sc-858. Western blot analysis of Bcl-6 expression in Ramos (A) and NAMALWA (B) whole cell lysates.
Bcl-6 (N-3): sc-858. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human lymphoma showing nuclear staining.
