epitope mapping at the C-terminus of TEL of human origin
recommended for detection of TEL of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
blocking peptide, sc-8547 P
TransCruz reagent for Gel Supershift and ChIP applications, sc-8547 X, 200 µg/0.1 ml
TEL Background Information Ets-1 is the prototype member of a family of genes identified on the basis of homology to the v-Ets oncogene isolated from the E26 erythroblastosis virus. Members of the Ets gene family exhibit varied patterns of tissue expression and share a highly conserved carboxy terminal domain containing a sequence related to the SV40 large T antigen nuclear localization signal sequence. This conserved domain is essential for Ets-1 binding to DNA and is likely to be responsible for the DNA binding activity of all members of the Ets gene family. Several of these proteins have been shown to recognize similar motifs in DNA that share a centrally located 5’-GGAA-3’ element. TEL (for translocation, Ets, leukemia), also designated ETV6, is a member of the Ets family that is involved in specific chromosomal translocations in human leukemia and sarcoma.
TEL (C-20) Product Citations
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TEL (C-20)
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TEL (C-20): sc-8547. Western blot analysis of TEL expression in CCRF-CEM whole cell lysate.
