epitope mapping within an internal region of IER3IP1 of human origin
recommended for detection of IER3IP1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine, bovine and porcine
IER3IP1 Background Information IER3IP1 (immediate early response 3-interacting protein 1) is also known as HSPC039 and is an 82 amino acid protein that is highly expressed in heart, skeletal muscle and kidney tissues. IER3IP1 is a multi-pass membrane protein with two transmembrane domains, localized to the endoplasmic reticulum through its C-terminal transmembrane domain. IER3IP1 may be involved in the transportation of proteins between the endoplasmic reticulum and the Golgi apparatus. IER3IP1 has a G-patch domain which is thought to function in the binding of RNA. The G-patch domain is associated with various proteins which exhibit functions which may include tumor suppression and DNA damage repair, suggesting that IER3IP1 may be involved in cellular responses to DNA damage. Matrine is a molecule that induces erythroid cell differentiation of K562 cells and the presence of the IER3IP1 gene is thought to increase matrine function, implying a possible role for IER3IP1 in erythroid cell differentiation.
