Sap 30 (yN-19) Antibody: sc-8474

Sap 30 Background Information
Sap30 is a subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci. Chromatin remodeling is a critical component of transcription regulation where acetylation of nucleosomal histones influences the shape of the chromatin. Acetylation results in an allosteric change in the nucleosomal conformation and an increased accessibility of DNA to transcription factors. Conversely, the deacetylation of histones is associated with transcriptional silencing. Gcn5 (also designated Ada4), Hat1 and Hat2 have been identified as yeast histone acetylases. Rpd3 (also designated SD12), Hda1 and Sap30 have been identified as histone deacetylases. Sin3 (also designated Rpd1, Gam2, Ume4 or Sdi1) is involved in the transcriptional repression of many genes.