TMTC4 Antibody (Y-19): sc-84645

---

The tetratricopeptide repeat (TPR) motif is a degenerate, 34 amino acid sequence found in many proteins and acts to mediate protein-protein interactions in various pathways. At the sequence level, there can be up to 16 tandem TPR repeats, each of which has a helix-turn-helix shape that stacks on other TPR repeats to achieve ligand binding specificity. TMTC4 (transmembrane and tetratricopeptide repeat containing 4) is a 741 amino acid multi-pass membrane protein that contains 8 TPR repeats and is expressed as multiple alternatively spliced isoforms. The gene encoding TMTC4 maps to human chromosome 13, which houses over 400 genes, such as BRCA2 and RB1, and comprises nearly 4% of the human genome.