epitope mapping near the C-terminus of IEX-1L of human origin
recommended for detection of IEX-1S and IEX-1L of human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
IEX-1 Background Information Tumors are frequently observed as resistant to apoptotic induction by FAS, tumor necrosis factor å (TNF-å) or irradiation. This anti-death activity may be attributed to immediate early-response genes that are regulated at the transcriptional level, including the protein IEX-1. IEX-1 was originally characterized as a gene induced by ultraviolet radiation and TNF-å, which protected human squamous carcinoma cells from apoptosis. Subsequent transfection studies have also shown that expression of IEX-1 in human keratinocytes and mouse fibroblasts results in more rapid proliferation of the cells as compared with controls. The promoter region of IEX-1 contains binding motifs for both NF-kB and p53, suggesting that these proteins may regulate its expression. IEX-1 is expressed as both a longer form (IEX-1L) and a splice variant, designated IEX-1S to indicate the shorter form, and it is localized to the nucleus and perinuclear region.
IEX-1 (C-20) Product Citations
See how others have used IEX-1 (C-20): sc-8454 antibody and or IEX-1 (C-20) antibody conjugates.
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IEX-1 (C-20)
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IEX-1 (C-20): sc-8454. Western blot analysis of IEX-1 expression in non-transfected: sc-117752 (A) and human IEX-1 transfected: sc-110039 (B) 293T whole cell lysates.
