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- mouse monoclonal IgG2a; 200 µg/ml
- raised against amino acids 1-205 mapping at the N-terminus of ΔN p63 of human origin
- recommended for detection of p63 isoforms of mouse, rat and human origin by WB, IP, IF, IHC(P), FCM and ELISA
- agarose conjugate for IP studies, p63 (4A4) AC: sc-8431 AC, 500 µg/0.25 ml agarose
- HRP conjugate, p63 (4A4) HRP: sc-8431 HRP, 200 µg/ml
- fluorescein (sc-8431 FITC), phycoerythrin (sc-8431 PE), PerCP (sc-8431 PerCP) and PerCP-Cy5.5 (sc-8431 PCPC5) conjugates for intracellular FCM, 100 tests
- Alexa Fluor® 488 (sc-8431 AF488) and Alexa Fluor® 647 (sc-8431 AF647) conjugates for FCM or immunofluorescence; 100 µg/2 ml
- This product is licensed for RESEARCH USE ONLY under U.S. Patents Nos. 6,946,256 and 7,030,227. Other uses of this SCBT product, for example in diagnostics and therapeutics, are outside the scope of the license and are not authorized. For products licensed for diagnostic use, consult AsymmetRx, Inc.
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Ordering InformationProduct Citations
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
TP63 |
8626 |
3q28 |
NM_003722 |
Q9H3D4
|
605289 |
| Mouse |
Trp63 |
22061 |
16 B1 |
|
O88898
|
N/A |
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p63 Background Information
The p53 gene is a widely studied anti-oncogene, or tumor suppressor gene. The p53 gene product can act as a negative regulator of cell growth in response to DNA damage. p73 shares a high degree of homology with p53, and appears to have similar growth inhibiting and apoptosis- promoting functions. However, unlike p53, the expression of p73 is not upregulated in response to DNA damage. p73 can, when overproduced, activate the p53-responsive gene p21. p63 has also been identified based on its similarities with p53. The p63 gene encodes multiple isotypes with variable functions. p63å (also designated p51B or KET), p63ß and p63g (also designated p51A), as well as corresponding TA* p63 isoforms, contain transactivation domains which have been shown to transactivate p53 reporter genes and induce apoptosis. DNp63 isoforms lack the transactivation domain and can act as dominant-negative reagents to inhibit trans-activation by p53 and p63.
| p63 (4A4) Product Citations |
See how others have used p63 (4A4): sc-8431 antibody and or p63 (4A4) antibody conjugates.
100 total citations Loading citations.
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p63 (4A4)
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p63 (4A4) PE: sc-8431 PE. Intracellular FCM analysis of fixed and permeabilized HeLa cells. Black line histogram represents the isotype control, normal mouse IgG 2a: sc-2867. p63 (4A4): sc-8431. Western blot analysis of p63 expression in human keratinocytes whole cell lysate.
p63 (4A4): sc-8431. Immunoperoxidase staining of formalin-fixed, paraffin-embedded normal human skin showing nuclear localization of p63 (A). Immunofluorescence staining of methanol-fixed A-431 cells showing nuclear staining (B).
p63 (4A4): sc-8431. Western blot analysis of p63 expression in C32 (A), NIH/3T3 (B) and KNRK (C) nuclear extracts.
p63 (4A4): sc-8431. Western blot analysis of p63 expression in Jurkat (A), THP-1 (B) and KNRK (C) nuclear extracts.
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