P-Selectin/CD62P/SELP Antibody (CTB201): sc-8419

P-Selectin Antibody (CTB201) is a mouse monoclonal IgG1 kappa light chain antibody that detects P-Selectin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). P-Selectin Antibody (CTB201) is available in both non-conjugated and various conjugated forms, including agarose, phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. P-Selectin, also known as GMP-140 or CD62P, plays a crucial role in the inflammatory response by mediating the adhesion of leukocytes to activated endothelial cells and platelets, which is essential for the recruitment of immune cells to sites of injury or infection. P-Selectin is primarily located on the surface of activated platelets and endothelial cells, where P-Selectin facilitates the rolling and adhesion of leukocytes, a critical step in the immune response. Proper functioning of P-Selectin is vital for maintaining vascular integrity and ensuring effective immune surveillance, making P-Selectin a significant target for research in inflammation and cardiovascular diseases. Anti-P-Selectin antibody (CTB201) is an invaluable tool for studying these processes and understanding the underlying mechanisms of various pathologies.

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P-Selectin/CD62P/SELP Antibody (CTB201) References:

1. P-selectin: a common therapeutic target for cardiovascular disorders, inflammation and tumour metastasis.  |  Ludwig, RJ., et al. 2007. Expert Opin Ther Targets. 11: 1103-17. PMID: 17665981
2. Targeting P-Selectin Adhesion Molecule in Molecular Imaging: P-Selectin Expression as a Valuable Imaging Biomarker of Inflammation in Cardiovascular Disease.  |  Perkins, LA., et al. 2019. J Nucl Med. 60: 1691-1697. PMID: 31601694
3. Circulating P-Selectin Glycoprotein Ligand 1 and P-Selectin Levels in Obstructive Sleep Apnea Patients.  |  Horváth, P., et al. 2020. Lung. 198: 173-179. PMID: 31897593
4. P-selectin targeted RAGE-shRNA lipoplexes alleviate atherosclerosis-associated inflammation.  |  Mocanu, CA., et al. 2021. J Control Release. 338: 754-772. PMID: 34530051
5. Selectin ligands.  |  Varki, A. 1994. Proc Natl Acad Sci U S A. 91: 7390-7. PMID: 7519775
6. Leukocyte trafficking mediated by selectin-carbohydrate interactions.  |  McEver, RP., et al. 1995. J Biol Chem. 270: 11025-8. PMID: 7538108
7. The cytoplasmic domain of L-selectin interacts with cytoskeletal proteins via alpha-actinin: receptor positioning in microvilli does not require interaction with alpha-actinin.  |  Pavalko, FM., et al. 1995. J Cell Biol. 129: 1155-64. PMID: 7538138
8. The selectins: vascular adhesion molecules.  |  Tedder, TF., et al. 1995. FASEB J. 9: 866-73. PMID: 7542213
9. Selectin-carbohydrate interactions and the initiation of the inflammatory response.  |  Lasky, LA. 1995. Annu Rev Biochem. 64: 113-39. PMID: 7574477
10. Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectins.  |  Frenette, PS., et al. 1996. Cell. 84: 563-74. PMID: 8598043
11. Platelet-mediated lymphocyte delivery to high endothelial venules.  |  Diacovo, TG., et al. 1996. Science. 273: 252-5. PMID: 8662511
12. Two selectins converge on sulphate. Leukocyte adhesion.  |  Rosen, SD. and Bertozzi, CR. 1996. Curr Biol. 6: 261-4. PMID: 8805242

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-P-Selectin/CD62P/SELP Antibody (CTB201) has 50 citations in a variety of scientific publications.

Primary antibodies like Anti-P-Selectin/CD62P/SELP Antibody (CTB201) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

P-Selectin/CD62P/SELP Antibody (CTB201) Specifications

Alternate Product Name: CD62

Product Clone Name: CTB201

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-830

Epitope Target: P-Selectin

Epitope Species: human

Product Reactivity/Detection: P-Selectin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), FCM

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 50 citations in various scientific publications

Available Conjugates/Forms for P-Selectin/CD62P/SELP Antibody (CTB201): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, PE: Phycoerythrin