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- mouse monoclonal IgG1; 200 µg/ml
- raised against amino acids 432-482 mapping at the C-terminus of HDAC1 of human origin
- recommended for detection of HDAC1 (also designated HD1) of mouse, rat and human origin by WB, IP, IF, FCM and ELISA
- TransCruz reagent for ChIP application, sc-8410 X, 200 µg/0.1 ml
- phycoerythrin conjugate for intracellular FCM, sc-8410 PE, 100 tests
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Ordering InformationProduct Citations
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
HDAC1 |
3065 |
1p35.1 |
NM_004964 |
Q13547
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601241 |
| Mouse |
Hdac1 |
433759 |
4 D2.2 |
|
O09106
|
N/A |
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HDAC1 Background Information
In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino-terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (for p300/CBP-associated factor), p300/CBP and the TFIID subunit TAF II p250. Mammalian HDAC1 (also designated HD1), HDAC2 (also designated mammalian RPD3) and HDAC3, all of which are related to the yeast transcriptional regulator Rpd3p, have been identified as histone deacetylases.
| HDAC1 (H-11) Product Citations |
See how others have used HDAC1 (H-11): sc-8410 antibody and or HDAC1 (H-11) antibody conjugates.
42 total citations Loading citations.
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HDAC1 (H-11)
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HDAC1 (H-11): sc-8410. Western blot analysis of HDAC1 expression in K-562 nuclear extract.
HDAC1 (H-11) PE: sc-8410 PE. Intracellular FCM analysis of fixed and permeabilized NIH/3T3 cells. Black line histogram represents the isotype control, normal mouse IgG 1: sc-2866. ChIP analysis of transcription regulatory proteins associated with the Pitx2 promoter in aT3-1 cells in response to lithium. Antibodies tested include LEF-1 (C-19): sc-8592 amd LEF-1 (N-17): sc-8591 (B), β-catenin (H-102): sc-7199, β-catenin (C-18): sc-1496 and β-catenin (E-5): sc-7963 (C), HDAC1 (H-11): sc-7872, HDAC1 (C-19): sc-6298 and HDAC1 (H-11): sc-8410 (D), HDAC2 (C-8): sc-9959, HDAC2 (H-54): sc-7899 and HDAC2 (C-19): sc-6296 (E). Input control (A). Data kindly provided by M.G. Rosenfeld and reproduced with permission from Kioussi et al., Cell 2002, 111: 673-685.
ChIP analysis of c-Myc promoter occupancy in response to lithium stimulation in serum synchronized C2C12 cells. Antibodies tested include HDAC1 (H-15): sc-7872, HDAC1 (C-19): sc-6298 and HDAC1 (H-11): sc-8410 (A), β-catenin (H-120): sc-7199, β-catenin (C-18): sc-1496 and β-catenin (E-5): sc-7963 (B), E2F-4 (A-20): sc-1082, E2F-4 (D-3): sc-6851, E2F-4 (RK-13): sc-511 and E2F-4 (C-20): sc-866 (C), and p130 (C-20): sc-317, p130 (211.6): sc-9963 and p130 (H-125): sc-20678 (D). Data kindly provided by M.G. Rosenfeld and reproduced with permission from Proc. Natl. Acad. Sci. 100: 3245-3250. Copyright 2003 National Academy of Sciences, USA. |
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