p-Elk-1 (B-4) Antibody: sc-8406

Elk-1 Background Information
Members of the Ets gene family exhibit varied patterns of tissue expression and share a highly conserved carboxy terminal domain containing a sequence related to the SV40 large T antigen nuclear localization signal sequence. This conserved domain is essential for Ets-1 binding to DNA and is likely responsible for the DNA binding activity of all members of the Ets gene family. ELK-1 is a 428 amino acid nuclear protein belonging to the Ets family. Expressed in lung and testis, ELK-1 stimulates transcription and binds to purine-rich DNA sequences. Upon mitogenic stimulation, ELK-1 is phosphorylated on C-terminal serine and threonine residues by MAPK1 (mitogen-activated protein kinase 1). Phosphorylation of ELK-1 leads to loss of SUMOylation and restores transcriptional activator activity. SUMOylation of ELK-1 results in recruitment of HDAC2 to target gene promoters, which leads to decreased histone acetylation and reduced transactivator activity.