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- mouse monoclonal IgG3; 200 µg/ml
- specific for an epitope mapping between amino acids 150-182 at the C-terminus of Cdc42 of human origin
- recommended for detection of Cdc42 of mouse, rat, human, Drosophila and Xenopus origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
- blocking peptide, sc-8401 P
- agarose conjugate for IP studies, sc-8401 AC, 500 µg/0.25 ml agarose
- HRP conjugate, sc-8401 HRP, 200 µg/ml
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Cdc42 Background Information
The superfamily of GTP-binding proteins, for which the Ras proteins are prototypes, has been implicated in regulation of diverse biological activities involving various aspects of cell growth and division. One mammalian member of the family, Cdc42, has an amino acid sequence that is similar to those of various members of the Ras superfamily proteins, including N-, K- and H-Ras, Rho proteins and the Rac proteins. On the basis of in vitro phosphorylation studies, it has been suggested that human Cdc42 may function in the signaling pathway of the EGF receptor or related growth factor receptor protein kinases. The Dbl oncogene has been shown to specifically catalyze dissociation of GDP from human Cdc42.
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See how others have used Cdc42 (B-8): sc-8401 antibody and or Cdc42 (B-8) antibody conjugates.
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Cdc42 (B-8)
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Cdc42 (B-8): sc-8401. Western blot analysis of Cdc42 expression in Jurkat (A) and 3611-RF (B) whole cell lysates.
Cdc42 (B-8): sc-8401 Immunoperoxidase staining of formalin fixed, paraffin-embedded human prostate tissue showing cytoplasmic staining of glandular cells. Kindly provided by The Swedish Human Protein Atlas (HPA) program.
Cdc42 (B-8): sc-8401. Western blot analysis of Cdc42 expression in non-transfected 293T: sc-117752 (A), human Cdc42 transfected 293T: sc-110467 (B) and Jurkat (C) whole cell lysates. Cdc42 (B-8): sc-8401. Western blot analysis of Cdc42 expression in Jurkat whole cell lysate.
Cdc42 (B-8): sc-8401. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.
Cdc42 (B-8): sc-8401. Western blot analysis of Cdc42 expression in Jurkat (A), 3611-RF (B), HeLa (C), THP-1 (D) and A-431 (E) whole cell lysates.
Cdc42 (B-8): sc-8401. Western blot analysis of Cdc42 expression in non-transfected: sc-117752 (A) and human Cdc42 transfected: sc-110467 (B) 293T whole cell lysates. |
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