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Ob-R Antibody (B-3): sc-8391

 |  Datasheet

(Based on data analysis)

  • Ob-R Antibody (B-3) is a mouse monoclonal IgG1 provided at 200 µg/ml
  • specific for an epitope mapping between amino acids 870-894 of short form Ob-R of mouse origin
  • recommended for detection of short and long forms of Ob-R of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including canine
  • blocking peptide, sc-8391 P
  • See 37 citations for Ob-R Antibody (B-3)
 

See additional Ob-R Antibodies.

Ordering InformationProduct CitationsGene Info
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   IHC(P)   siRNA  
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
Ob-R Antibody (B-3) sc-8391 200 µg/ml $279
Ob-R (B-3) P sc-8391 P
(peptide)
100 µg/0.5 ml $61
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Ob-R siRNA (h) sc-36115 10 µM $258
Ob-R siRNA (m) sc-36116 10 µM $258
Ob-R (h)-PR sc-36115-PR 10 µM, 20 µl $23
Ob-R (m)-PR sc-36116-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Ob-R shRNA Plasmid (h) sc-36115-SH 20 µg $520
Ob-R shRNA Plasmid (m) sc-36116-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Ob-R shRNA (h) Lentiviral Particles sc-36115-V 200 µl $625
Ob-R shRNA (m) Lentiviral Particles sc-36116-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
rat brain extract sc-2392 500 µg/200 µl $104
COLO 320DM Cell Lysate sc-2226 500 µg/200 µl $104
KNRK Whole Cell Lysate sc-2214 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human LEPR 3953 1p31.3 NM_001003679, NM_001003680, NM_002303 P48357
601007
Mouse Lepr 16847 4 C6 P48356
N/A
 


Although there is substantial evidence that body weight is physiologically regulated, the molecular basis of obesity is unknown. Five single-gene mutations in mice that result in an obese phenotype have been identified. The first such recessive obesity mutation, the obese mutation (Ob), was identified in 1950. Mutation of Ob results in profound obesity and type II diabetes as part of a syndrome that resembles morbid obesity in humans. It has been postulated that the Ob gene product may function as a component of a signaling pathway in adipose tissue that functions to regulate body fat depot size. The cloning and sequence analysis of the mouse Ob gene and its human homolog has recently been described. Ob encodes an adipose tissue-specific mRNA with a highly conserved 167 amino acid open reading frame. The predicted amino acid sequence is 84% identical between human and mouse and has the features of a secreted protein. A nonsense mutation in codon 105 has been found in the original congenic C57BL/6J Ob/Ob mouse strain. The Ob gene encodes the protein leptin. The leptin receptor, designated Ob-R, has been shown to be a single membrane-spanning receptor that most resembles the gp130 signal transducing component of the IL-6, G-CSF and LIF receptor. Ob-R mRNA is expressed in the choroid plexus and hypothalamus.

Ob-R Antibody (B-3) Product Citations
See how others have used Ob-R Antibody (B-3) and or Ob-R Antibody (B-3) conjugates.


37 total citations
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Ob-R Antibody (B-3) Data
Click on image to enlarge
Ob-R (B-3): sc-8391. Western blot analysis of Ob-R expression in COLO 320DM whole cell lysate.
Ob-R (B-3): sc-8391. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human colon carcinoma showing membrane localization.
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