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- rabbit polyclonal IgG, 200 µg/ml
- epitope corresponding to amino acids 451-620 of PRC1 of human origin
- recommended for detection of PRC1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine and canine
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PRC1 Background Information
Sequential activation and inactivation of Cdk/cyclin complexes regulates the cell cycle. PRC1 (for protein regulating cytokinesis 1) has been identified as a substrate for several Cdks, including Cdc2 and Cdk2. PRC1 binds to the midzone of mitotic spindles during anaphase and is localized to the cell midbody during cytokinesis. Depletion of PRC1 has been shown to prevent cellular cleavage, but it has no effect on nuclear division, demonstrating the importance of PRC1 in mitosis. The yeast homolog of PRC1, Ase1, is essential for spindle assembly, elongation and disassembly during mitosis. Ase1 has been shown to undergo degradation mediated by the APC (anaphase-promoting complex) upon entry into G1 phase.
| PRC1 (H-70) Product Citations |
See how others have used PRC1 (H-70): sc-8356 antibody and or PRC1 (H-70) antibody conjugates.
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PRC1 (H-70)
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PRC1 (H-70) : sc-8356. Western blot analysis of PRC1 expression in HeLa whole cell lysate (A) and mouse embryo tissue extract (B).
PRC1 (H-70): sc-8356. Immunofluorescence staining of normal mouse intestine frozen section showing nuclear staining.
PRC1 (H-70): sc-8356. Western blot analysis of PRC1 expression in non-transfected 293T: sc-117752 (A), mouse PRC1 transfected 293T: sc-127378 (B) and HeLa (C) whole cell lysates. PRC1 (H-70): sc-8356. Immunoperoxidase staining of formalin fixed, paraffin-embedded human bronchus tissue showing nuclear and cytoplasmic staining of respiratory epithelial cells and interstitial cells.
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