santa cruz biotechnology, inc.
SCBT Logo

Welcome!        Items in Cart     Quick Order
home » Cell Cycle Proteins » Cdc Antibody / Cdc Antibodies » Cdc6 (H-304): sc-8341

Cdc6 (H-304) Antibody: sc-8341

  |  Datasheet
  • rabbit polyclonal IgG, 200 µg/ml
  • epitope corresponding to amino acids 257-560 of Cdc6 of human origin
  • recommended for detection of Cdc6 p62 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
 
Additional Cdc Antibodies ...
 
Ordering InformationProduct Citations
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   IHC(P)   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human CDC6 990 17q21.2 NM_001254 Q99741
 602627
Mouse Cdc6 23834 11 D O89033
 N/A
 
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
Cdc6 (H-304) sc-8341 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Cdc6 siRNA (h) sc-29258 10 µM $258
Cdc6 siRNA (m) sc-35046 10 µM $258
Cdc6 (h)-PR sc-29258-PR 10 µM $23
Cdc6 (m)-PR sc-35046-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Cdc6 shRNA Plasmid (h) sc-29258-SH 20 µg $520
Cdc6 shRNA Plasmid (m) sc-35046-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Cdc6 shRNA (h) Lentiviral Particles sc-29258-V 200 µl $625
Cdc6 shRNA (m) Lentiviral Particles sc-35046-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
HeLa nuclear extract sc-2120 1000 µg $143
Jurkat Whole Cell Lysate sc-2204 500 µg/200 µl $104
HeLa Whole Cell Lysate sc-2200 500 µg/200 µl $104
NIH/3T3 Whole Cell Lysate sc-2210 500 µg/200 µl $104
Jurkat nuclear extract sc-2132 1000 µg $143

Cdc6 Background Information
Cell cycle events are regulated by the sequential activation and deactivation of cyclin dependent kinases (Cdks) and by the proteolysis of cyclins. The cell division control (Cdc) genes are required at various points in the cell cycle. Cdc25A, Cdc25B and Cdc25C protein Tyrosine phosphatases function as mitotic activators by dephosphorylating Cdc2 p34 on regulatory Tyrosine residues. Cdc6 is the human homolog of Saccharomyces cerevisiae Cdc6, which is involved in the initiation of DNA replication. Cdc37 appears to facilitate Cdk4/cyclin D1 complex formation and has been shown to form a stable complex with HSP 90. Cdc34, Cdc27 and Cdc16 function as ubiquitin-conjugating enzymes. Cdc34 is thought to be the structural and functional homolog of Saccharomyces cerevisiae Cdc34, which is essential for the G1 to S phase transition. Cdc16 and Cdc27 are components of the APC (anaphase-promoting complex) which ubiquitinates cyclin B, resulting in cyclin B/Cdk complex degradation.

Cdc6 (H-304) Product Citations
See how others have used Cdc6 (H-304): sc-8341 antibody and or Cdc6 (H-304) antibody conjugates.


12 total citations
Loading citations.
 
Cdc6 (H-304)
Click on image to enlarge
sc-8341
Cdc6 (H-304): sc-8341. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast tumor showing cytoplasmic and nuclear staining.
sc-8341
Cdc6 (H-304): sc-8341. Western blot analysis of Cdc6 expression in Jurkat whole cell lysate.
sc-8341
Cdc6 (H-304): sc-8341. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.
sc-8341
Cdc6 siRNA (h): sc-29258. Immunofluorescence staining of methanol-fixed, control HeLa (A) and Cdc6 siRNA silenced HeLa (B) cells showing diminished cytoplasmic staining in the siRNA silenced cells. Cells probed with Cdc6 (H-304): sc-8341.
sc-8341
Cdc6 (H-304): sc-8341. Western blot analysis of Cdc6 expression in HeLa (A) and NIH/3T3 (B) whole cell lysates and Jurkat (C) and HeLa (D) nuclear extracts.
sc-8341
Cdc6 (H-304): sc-8341. Western blot analysis of Cdc6 expression in HeLa whole cell lysate (A) and HeLa nuclear extract (B).
sc-8341
Cdc6 (H-304): sc-8341. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.
Download
Datasheets
Get Adobe Acrobat Reader