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- rabbit polyclonal IgG, 100µg/ml
- epitope mapping within an internal region of WDR4 of human origin
- recommended for detection of WDR4 of mouse, rat and human origin by WB, IP, IF and ELISA; non cross-reactive with family member WDR5; also reactive with additional species, including equine, bovine and porcine
- blocking peptide, sc-83348 P
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Ordering Information
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
WDR4 |
10785 |
21q22.3 |
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P57081
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605924 |
| Mouse |
Wdr4 |
57773 |
17 B1 |
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Q9EP82
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N/A |
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WDR4 Background Information
WD-repeats are motifs that are found in a variety of proteins and are characterized by a conserved core of 40-60 amino acids that commonly form a tertiary propeller structure. While proteins that contain WD-repeats participate in a wide range of cellular functions, they are generally involved in regulatory mechanisms concerning chromatin assembly, cell cycle control, signal transduction, RNA processing, apoptosis and vesicular trafficking. WDR4 (WD-repeat-containing protein 4), also known as TRM82, is a 412 amino acid protein that contains two WD-repeats. Expressed as multiple isoforms due to alternative splicing events, WDR4 forms a complex with METTL1 (methyltransferase like 1) that is necessary for the 7-methylguanosine modification of tRNA. Defects in the gene encoding WDR4 may be associated with the development of Down syndrome, a chromosomal disorder characterized by deformed physical features and mental retardation. |
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WDR4 (S-20)
Click on image to enlarge
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WDR4 (S-20): sc-83348. Western blot analysis of WDR4 expression in non-transfected: sc-117752 (A) and mouse WDR4 transfected: sc-124624 (B) 293T whole cell lysates. |
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