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Smad2/3 (FL-425) Antibody: sc-8332 |
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- rabbit polyclonal IgG, 200 µg/ml
- raised against amino acids 1-425 representing full length Smad3 of human origin
- recommended for detection of Smad2 and Smad3 and, to a lesser extent, Smad5, Smad1 and Smad8 of mouse, rat and human origin by WB, IP, IF IHC(P)and ELISA; also reactive with additional species, including canine, bovine, porcine and avian
- TransCruz reagent for Gel Supershift and ChIP applications, sc-8332 X, 200 µg/0.1 ml
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Smad2/3 Background Information
Smad proteins, the mammalian homologs of the Drosophila mothers against decapentaplegic (Mad), have been implicated as downstream effectors of TGF∫/BMP signaling. Smad1 (also designated Madr1 or JV4-1) and Smad5 are effectors of BMP-2 and BMP-4 function, while Smad2 (also designated Madr2 or JV18-1) and Smad3 are involved in TGF∫ and Activin-mediated growth modulation. Smad4 (also designated DPC4) has been shown to mediate all of the above activities through interaction with various Smad family members. Smad6 and Smad7 regulate the response to Activin/TGF∫ signaling by interfering with TGF∫-mediated phosphorylation of other Smad proteins.
| Smad2/3 (FL-425) Product Citations |
See how others have used Smad2/3 (FL-425): sc-8332 antibody and or Smad2/3 (FL-425) antibody conjugates.
61 total citations Loading citations.
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Smad2/3 (FL-425)
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Smad2/3 (FL-425): sc-8332. Western blot analysis of Smad2 and Smad3 expression in K-562 whole cell lysate.
Smad2/3 (FL-425): sc-8332. Western blot analysis of Smad3 expression in non-transfected: sc-117752 (A) and human Smad3 transfected: sc-116400 (B) 293T whole cell lysates. Smad2/3 (FL-425): sc-8332. Western blot analysis of Smad3 expression in non-transfected: sc-117752 (A) and mouse Smad3 transfected: sc-123640 (B) 293T whole cell lysates. Smad2/3 (FL-425): sc-8332. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.
Smad2/3 (FL-425): sc-8332. Western blot analysis of Smad2/3 expression in K-562 (A), U-937 (B) and C2C12 (C) whole cell lysates.
Smad2/3 (FL-425): sc-8332. Immunoperoxidase staining of formalin fixed, paraffin-embedded human bronchus tissue showing nuclear and cytoplasmic staining of respiratory epithelial cells.
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