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home » Kinases and Phosphatases » GRK Antibody / GRK Antibodies » GRK 2/3 (H-222): sc-8329

GRK 2/3 (H-222) Antibody: sc-8329

  |  Datasheet
  • rabbit polyclonal IgG, 200 µg/ml
  • epitope raised against amino acids 468-689 mapping at the C-terminus of GRK 2 of human origin
  • recommended for detection of GRK 2 and GRK 3 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
 
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Ordering InformationProduct Citations
Recommended Support Products:
(click button of application of choice)
WB   IP   IF  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human ADRBK1 156 11q13.1 NM_001619 P25098
 109635
Mouse Adrbk1 110355 19 A Q99MK8
 N/A
Mouse Adrbk2 320129 5 F Q3UYH7
 N/A
 
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
GRK 2/3 (H-222) sc-8329 200 µg/ml $279
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
GRK 3 (h): 293T Lysate sc-115361 100µg/200µl $205
HL-60 Whole Cell Lysate sc-2209 500 µg/200 µl $104
A-431 Whole Cell Lysate sc-2201 500 µg/200 µl $104
GRK 2 (h2): 293T Lysate sc-115352 100µg/200µl $205
Ramos Cell Lysate sc-2216 500 µg/200 µl $104
GRK 2 (h): 293T Lysate sc-111619 100µg/200µl $205
BJAB Whole Cell Lysate sc-2207 500 µg/200 µl $104

GRK 2/3 Background Information
Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. This phenomenon, referred to as agonist-mediated desensitization, involves phosphorylation of the receptor by two classes of enzymes. The first class is comprised of the second messenger-regulated kinases, such as c-AMP dependent protein kinase A and protein kinase C. The second class includes the G protein-coupled receptor kinases (GRKs). At least seven members of the GRK family have been identified. These include rhodopsin kinase (GRK 1), two forms of ∫-adrenergic receptor kinase: GRK 2 (∫ARK, ∫ARK1) and GRK 3 (∫ARK2), IT-11 (GRK 4), GRK 5, GRK 6 and GRK 7. Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state.

GRK 2/3 (H-222) Product Citations
See how others have used GRK 2/3 (H-222): sc-8329 antibody and or GRK 2/3 (H-222) antibody conjugates.


5 total citations
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GRK 2/3 (H-222)
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sc-8329
GRK 2/3 (H-222): sc-8329. Western blot analysis of GRK 2/3 expression in Ramos whole cell lysate.
sc-8329
GRK 2/3 (H-222): sc-8329. Immunofluorescence staining of methanol-fixed Ramos cells showing cytoplasmic and membrane staining.
sc-8329
GRK 2/3 (H-222): sc-8329. Western blot analysis of GRK 2 expression in non-transfected 293T: sc-117752 (A), human GRK 2 transfected 293T: sc-115352 (B) and A-431 (C) whole cell lysates.
sc-8329
GRK 2/3 (H-222): sc-8329. Western blot analysis of GRK 2 expression in non-transfected: sc-117752 (A) and human GRK 2 transfected: sc-111619 (B) 293T whole cell lysates.
sc-8329
GRK 2/3 (H-222): sc-8329. Western blot analysis of GRK 3 expression in non-transfected 293T: sc-117752 (A), human GRK 3 transfected 293T: sc-115361 (B) and BJAB (C) whole cell lysates.
sc-8329
GRK 2/3 (H-222): sc-8329. Western blot analysis of GRK 2 expression in non-transfected: sc-110760 (A) and human GRK 2 transfected: sc-158576 (B) 293 whole cell lysates.
sc-8329
GRK 2/3 (H-222): sc-8329. Western blot analysis of GRK 2 expression in non-transfected 293T: sc-117752 (A), human GRK 2 transfected 293T: sc-172730 (B) and BJAB (C) whole cell lysates.
sc-8329
GRK 2/3 (H-222): sc-8329. Western blot analysis of GRK 2 expression in non-transfected 293T: sc-117752 (A), mouse GRK 2 transfected 293T: sc-120637 (B) and BJAB (C) whole cell lysates.
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