RYK Background Information RYK (related to receptor tyrosine kinase) is a chemorepulsive axon guidance receptor required for establishing major axon tracts, such as the corticospinal tract and the corpus callosum, in the developing nervous system. RYK belongs to the RTK family and is ubiquitously expressed in both developing and adult tissues. Compared to other RTK family members, RYK has a relatively short extracellular domain. In addition, RYK contains two N-terminal leucine-rich motifs that resemble the N-terminal domain of WIF-1. RYK functions as a Wnt receptor and produces a repulsive guidance signal upon binding of Wnt-1, 3, 3a or 5a to its WIF-like domain. The loss of functional RYK results in the formation of contralateral axon bundles and the disruption of cardiac, skeletal and craniofacial development, ultimately resulting in perinatal death. RYK is also strongly expressed in malignant ovarian tumors and may play a role in tumorigenesis.
RYK (F35 P7 D7 F5)
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RYK (F35 P7 D7 F5): sc-83082. Western blot analysis of RYK expression in HCT116 cell extract.
