epitope corresponding to amino acids 1110-1223 mapping at the C-terminus of Jagged1 of human origin
recommended for detection of Jagged1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
Jagged1 Background Information The LIN-12/Notch family of transmembrane receptors is believed to play a central role in development by regulating cell fate decisions. Ligands for Notch include Jagged1, Jagged2 and Delta. Jagged is a membrane protein and can activate Notch and prevent myoblast differentiation by inhibiting the expression of muscle regulatory and structural genes. It is involved in mammalian cardiovascular development and in cell-fate decisions during hematopoiesis. Jagged is expressed in adult and fetal tissues, and expression is upregulated in cervical squamous cell carcinoma. Familial Tetralogy of Fallot, the most common form of complex congenital heart disease, is caused by a mutation in the Jagged1 gene.
Jagged1 (H-114) Product Citations
See how others have used Jagged1 (H-114): sc-8303 antibody and or Jagged1 (H-114) antibody conjugates.
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Jagged1 (H-114)
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Jagged1 (H-114): sc-8303. Immunofluorescence staining of methanol-fixed RAW 264.7 cells showing cell surface localization.
Western blot analysis of Jagged expression in mouse embryo extract (A) and RAW 264.7 whole cell lysate (B). Antibodies tested include Jagged1 (C-20): sc-6011 (A) and Jagged1 (H-114): sc-8303 (B).
Jagged1 (H-114): sc-8303. Immunoperoxidase staining of formalin fixed, paraffin-embedded human gall bladder tissue showing membrane staining of glandular cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.
