BANP Background Information BANP (BTG3 associated nuclear protein), also known as BEND1, SMARBP1 or SMAR1, is a 519 amino acid protein that localizes to the nucleus and belongs to the BANP/SMAR1 family. Interacting with CDP and p53, BANP functions to control V(D)J recombination during T-cell development, specifically by binding to a scaffold/matrix DNA attachment region and repressing the enhancer function of TCR∫ (T-cell receptor beta). Additionally, BANP promotes p53 serine phosphorylation, resulting in the subsequent nuclear accumulation of p53 and, ultimately, cell cycle arrest. BANP is down regulated in breast cancer cells, suggesting a role in tumor suppression. Three isoforms of BANP exist due to alternative splicing events.
