XCR1 Background Information G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. G protein coupled receptors translate extracellular signals into intracellular signals (G protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. XCR1, also known as GPR5 (G-protein coupled receptor 5) or CCXCR1 (chemokine (C motif) receptor 1), is a 333 amino acid multi-ass membrane protein that belongs to the G-protein coupled receptor 1 family. Functioning as a receptor for select chemokines, XCR1 transduces cellular signals by increasing intracellular calcium ion levels.
