epitope mapping at an internal region of RBP-Jκ of human origin
recommended for detection of RBP-Jκ of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
blocking peptide, sc-8213 P
TransCruz reagent for Gel Supershift and ChIP applications, sc-8213 X, 200 µg/0.1 ml
RBP-Jκ Background Information Recombination signal binding protein J˚ (RBP-J˚), also designated KBF2 or CBF1, is the mammalian homolog of the Drosophila Suppressor of Hairless [Su(H)], a protein involved in the development of the peripheral nervous system. RBP-J˚ is ubiquitously expressed in mammalian tissues and is involved in the regulation of gene expression. RBP-J˚ has been shown to directly interact with the intercellular domain of the cell surface receptor Notch 1. Proteolytically cleaved Notch 1 translocates to the nucleus, where it binds DNA-bound RBP-J˚ and activates transcription of target genes. These genes include NF˚B p52 and the Epstein-Barr virus (EBV) protein EBNA-2, both of which contain RBP-J˚-binding sequences within their promoter regions.
RBP-Jκ (D-20) Product Citations
See how others have used RBP-Jκ (D-20): sc-8213 antibody and or RBP-Jκ (D-20) antibody conjugates.
