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- rabbit polyclonal IgG, 200 µg/ml
- epitope mapping at the N-terminus of p35 of human origin
- recommended for detection of p35 precursor of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
- blocking peptide, sc-821 P
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Ordering InformationProduct Citations
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
CDK5R1 |
8851 |
17q11.2 |
NM_003885 |
Q15078
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603460 |
| Mouse |
Cdk5r1 |
12569 |
11 B5 |
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P61809
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N/A |
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p35 Background Information
Cyclin dependent kinase-5 (Cdk5), a key regulator of cell cycle progression, was originally isolated on the basis of its structural homology to Cdc2, a well-characterized regulator of cell cycle progression. Although Cdk5 is expressed at the highest level in the brain of adult mice, intermediate levels in testis and low or undetectable levels in all other tissues, brain is the only tissue from which Cdk5 can be isolated as an active kinase. These findings may be explained by the cloning and characterization of a Cdk5 regulatory subunit, designated p35. p35 displays a neuronal cell-specific pattern of expression, physically associates with Cdk5 and activates Cdk5 enzymatic activity. p35 is also expressed in many tissues in a truncated form, designated p25.
| p35 (N-20) Product Citations |
See how others have used p35 (N-20): sc-821 antibody and or p35 (N-20) antibody conjugates.
19 total citations Loading citations.
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p35 (N-20)
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p35 (N-20): sc-821. Western blot analysis of p35 expression in non-transfected: sc-117752 (A) and human p35 transfected: sc-113375 (B) 293T whole cell lysates. |
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