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home » Tumor Suppressors/Apoptosis » Menin Antibody / Menin Antibodies » Menin (C-19): sc-8200

Menin (C-19) Antibody: sc-8200

  |  Datasheet
  • goat polyclonal IgG, 200 µg/ml
  • epitope mapping at the C-terminus of Menin of human origin
  • recommended for detection of Menin of mouse, rat and human origin by WB, IP, IF, FCM and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
  • phycoerythrin conjugate for intracellular FCM, sc-8200 PE, 100 tests
  • blocking peptide, sc-8200 P
 
Additional Menin Antibodies ...
 
Ordering InformationProduct Citations
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   FCM   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human MEN1 4221 11q13.1 NM_000244, NM_130799, NM_130800, NM_130801, NM_130802, NM_130803, NM_130804 O00255
 145000
Mouse Men1 17283 19 A O88559
 N/A
 
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
Menin (C-19) sc-8200 200 µg/ml $279
Menin (C-19) P sc-8200 P
(peptide)
 100 µg/0.5 ml $61
Menin (C-19) PE sc-8200 PE 100 tests in 2ml $303
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Menin siRNA (h) sc-35922 10 µM $258
Menin siRNA (m) sc-35923 10 µM $258
Menin (h)-PR sc-35922-PR 10 µM $23
Menin (m)-PR sc-35923-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Menin shRNA Plasmid (h) sc-35922-SH 20 µg $520
Menin shRNA Plasmid (m) sc-35923-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Menin shRNA (h) Lentiviral Particles sc-35922-V 200 µl $625
Menin shRNA (m) Lentiviral Particles sc-35923-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
K-562 nuclear extract sc-2130 1000 µg $143
Jurkat + PMA nuclear extract sc-2133 1000 µg $143
A-431 nuclear extract sc-2122 1000 µg $143

Menin Background Information
Menin (multiple endocrine neoplasia I, MEN1, MEAI, SCG2) is a nuclear tumor suppressor that is mutated in patients with multiple endocrine neoplasia type I (MEN1). Menin can activate the transcription of differentiation-regulating genes by covalent histone modification. In osteoblasts, the interaction of menin and the TGF∫eta/Smad3 pathway negatively regulates BMP2/Smad1/5- and Runx2-dependent transcription activities leading to inhibition of late-stage differentiation. Menin regulates the expression of IGFBP-2 by influencing the IGFBP-2 promoter. Ectopic overexpression of menin via adenoviruses induces apoptosis in murine embryonic fibroblasts in a Bax/Bak-dependent manner. Two mRNA exist and two variants of the shorter mRNA have alternative splicing that changes the CDS. Five variants where alternative splicing takes place in the 5' UTR have been identified.

Menin (C-19) Product Citations
See how others have used Menin (C-19): sc-8200 antibody and or Menin (C-19) antibody conjugates.


11 total citations
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Menin (C-19)
Click on image to enlarge
sc-8200
Menin (C-19) PE: sc-8200 PE. Intracellular FCM analysis of fixed and permeabilized A431 cells. Black line histogram represents the isotype control, normal goat IgG: sc-3992.
sc-8200
Menin (C-19): sc-8200. Western blot analysis of Menin expression in phorbol-induced Jurkat (A), K-562 (B) and A-431 (C) nuclear extracts.
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