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Meis2 Antibody (63-T): sc-81986

 |  Datasheet

(Based on data analysis)

  • Meis2 Antibody (63-T) is a mouse monoclonal IgG1 provided at 100 µg/ml
  • raised against recombinant Meis2 of human origin
  • recommended for detection of Meis2 of human origin by WB, IP, IF, IHC(P) and ELISA
 

See additional Meis Antibodies including Meis, Meis1, Meis2 and Meis3.

Ordering InformationGene Info
Recommended Support Products:
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WB   IP   IF   IHC(P)   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
Meis2 Antibody (63-T) sc-81986 100 µg/ml $295
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Meis2 siRNA (h) sc-38794 10 µM $258
Meis2 (h)-PR sc-38794-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Meis2 shRNA Plasmid (h) sc-38794-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Meis2 shRNA (h) Lentiviral Particles sc-38794-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
HeLa Whole Cell Lysate sc-2200 500 µg/200 µl $104
Meis2 (h): 293T Lysate sc-116143 100 µg/200 µl $205
Meis2 (h3): 293T Lysate sc-177533 100 µg/200 µl $205
Meis2 (h4): 293T Lysate sc-177534 100 µg/200 µl $205
MEG-01 Cell Lysate sc-2283 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human MEIS2 4212 15q14 NM_002399, NM_020149, NM_170674, NM_170675, NM_170676, NM_170677, NM_172315, NM_172316 O14770
601740
 


Hox, Pbx and Meis families of transcription factors form heteromeric complexes and bind DNA through specific homeobox domains. Hox proteins are involved in regulating tissue patterning during development, and are also expressed in lineage- and stage-specific patterns during adult hematopoietic differentiation and in leukemias. The Hox proteins, which include paralog groups 1-10, have a low intrinsic binding affinity for DNA and are instead associated into cooperative DNA binding complexes with Pbx or the Pbx- related Meis proteins, which result in an enhanced Hox-DNA binding affinity and an increased selectivity for the binding site. Both Meis1 and Meis2 (also known as Meis-related gene 1 or Mrg1) are members of the TALE (“three amino acid loop extension”) family of homeodomain-containing proteins. In addition to binding with Hox proteins, Meis1 also forms heterodimers with the ubiquitously expressed Pbx proteins, including Pbx1, Pbx2 and Pbx3, and these complexes contain distinct DNA-binding specificities. Like Hox and Pbx proteins, Meis1 is implicated in oncogenesis, as it is overexpressed as a result of adjacent retroviral insertion in BHX-2 myeloid leukemias. Two Meis-related proteins, Meis2 and Meis3 (also designated Mrg1 and Mrg2, respectively), possess largely similar sequence identity with Meis1 and are expressed in normal tissues and myeloid leukemias. In the pancreas, Meis2 preferentially associates with Pbx1, and together they associate with the pancreas-specific homeodomain factor, Pdx1, to repress Pdx1-induced transcriptional activation.

Meis2 Antibody (63-T) Data
Click on image to enlarge
Meis2 (63-T): sc-81986. Western blot analysis of Meis2 expression in HeLa whole cell lysate.
Meis2 (63-T): sc-81986. Immunofluorescence staining of paraformaldehyde-fixed HeLa cells showing nuclear localization.
Meis2 (63-T): sc-81986. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human spleen tissue showing nuclear localization.
Meis2 (63-T): sc-81986. Western blot analysis of Meis2 expression in non-transfected: sc-117752 (A) and human Meis2 transfected: sc-116143 (B) 293T whole cell lysates.
Meis2 (63-T): sc-81986. Western blot analysis of Meis2 expression in non-transfected 293T: sc-117752 (A), human Meis2 transfected 293T: sc-177533 (B) and MEG-01 (C) whole cell lysates.
Meis2 (63-T): sc-81986. Western blot analysis of Meis2 expression in non-transfected 293T: sc-117752 (A), human Meis2 transfected 293T: sc-177534 (B) and MEG-01 (C) whole cell lysates.
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