Ral GPS2 (FE-63) Antibody: sc-81899

Ral GPS2 Background Information
Ral GPS2 (Ral GEF with PH domain and SH3 binding motif 2) is a 583 amino acid member of the Ral GPS family and functions as a guanine nucleotide-exchange factor (GEF) for the small GTPase Ral A. Members of the Ral GPS family of GEFs are distinct from other Ral GEFs in that they lack the Ras-GTP-binding domain and are therefore activated in a Ras-independent manner. Expressed in testis and brain, Ral GPS2 localizes to the cytoplasm and contains one Ras-GEF domain and one PH domain. Via its PH domain, Ral GPS2 can associate with the cell membrane and can bind to phosphatidylinositol 4,5-bisphosphate. In addition, Ral GPS2 interacts with GRB2 and PLC ©1 and may function in cytoskeleton organization and Ras-independent stimulation of transcription. Mutations in the gene encoding Ral GPS2 are implicated in the development of Alzheimer disease (AD).