KCNC3 (Y-31) Antibody: sc-81880

KCNC3 Background Information
KCNC3 (Potassium voltage-gated channel subfamily C member 3) is a multi-pass membrane-bound protein that acts as an ion channel and is generally expressed as a heterotetramer of potassium channeling proteins. The corneal epithelium is an important cell layer that functions to separate the corneal stroma from the anterior chamber of the eye. Increased expression of KCNC3 in confluent corneal endothelial cells suggests that the ionic current maintained by KCNC3 acts to regulate the hydration and transparency of the corneal stroma. Potassium channel regulation is also important for the high-frequency firing of cerebellar neurons. Defects, primarily missense mutations, in the gene encoding the KCNC3 protein have been attributed to neurological developmental disorders and adult onset neurological diseases.