AlaRS (M6-P2E5) Antibody: sc-81712

AlaRS Background Information
Aminoacyl-tRNA synthetases function to catalyze the aminoacylation of tRNAs by their corresponding amino acids, thus linking amino acids with tRNA-contained nucleotide triplets. Class II tRNA synthases are a highly conserved subfamily of tRNA synthetases that have a catalytic domain through which they interact with the amino acid acceptor of the tRNA and a second domain through which they interact with the rest of the tRNA molecule. AlaRS (alanyl-tRNA synthetase), also known as AARS, is a 968 amino acid cytoplasmic protein that belongs to the class II subfamily of tRNA synthases. Functioning as a monomer, AlaRS catalyzes the ATP-dependent attachment of alanine to a corresponding tRNA(Ala), thereby producing alanyl-tRNA(Ala). Defects in the gene encoding AlaRS may lead to an accumulation of misfolded proteins within the cell, ultimately leading to cell death.