epitope mapping near the C-terminus of Wig-1 of mouse origin
recommended for detection of Wig-1 of mouse and rat origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
Wig-1 Background Information p53 is a DNA-binding protein that is involved in a variety of processes, including tumor suppression and apoptosis, DNA replication and repair, and cell cycle regulation (1,2). Normal cells and tissues express a low level of p53 under most circumstances, but p53 expression is induced by DNA damage and cellular
stress (3,4). Wig-1 (wild type p53-induced gene 1) is a zinc finger protein that contains a putative nuclear localization signal (NLS) and is induced by p53. Wig-1 expression is increased by whole body gamma irradiation in these tissues as well as in spleen and lung (5).
