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- rabbit polyclonal IgG, 200 µg/ml; also available as goat IgG, 200 µg/ml, sc-816-G
- epitope mapping at the N-terminus of AR of human origin
- recommended for detection of androgen receptor of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
- blocking peptide, sc-816 P
- TransCruz reagent for Gel Supershift and ChIP applications, sc-816 X, 200 µg/0.1 ml
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Ordering InformationProduct Citations
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AR Background Information
Androgens exhibit a wide range of effects on the development, maintenance and regulation of male phenotype and male reproductive physiology. The androgen receptor (AR) is a member of the steroid superfamily of ligand-dependent transcription factors. ARs bind the two biologically active androgens, testosterone (T) and dihydrotestosterone (DHT), with high and nearly identical affinities; however, the rates of association and dissociation of T are about three times more rapid than those of DHT. This difference has resulted in speculation as to whether these differences in binding kinetics could account for the different physiological effects of T and DHT. A striking feature of AR is its rapid degradation in the absence of ligand. It is now well established that androgen binding results in an at least six-fold increase in androgen stability and that ligand-induced stabilization of AR is highly androgen- specific.
| AR (N-20) Product Citations |
See how others have used AR (N-20): sc-816 antibody and or AR (N-20) antibody conjugates.
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AR (N-20)
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Western blot analysis of AR expression in AT-3 (A), T-47D (B), ZR-75-1 (C,F) and MCF7 (D) whole cell lysates and SK-BR-3 nuclear extract (E). Antibodies tested include AR (N-20): sc-816 (A-E) and AR (441): sc-7305 (F). AR (N-20): sc-816. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human prostate carcinoma tissue showing nuclear staining of glandular epithelia (A). Immunofluorescence staining of methanol-fixed LNCaP cells showing nuclear localization (B).
AR (N-20): sc-816. Western blot analysis of AR expression in T-47D (A), ZR-75-1 (B), MCF7 (C), LNCaP (D) and AT-3 (E) whole cell lysates.
AR (N-20): sc-816. Western blot analysis of AR expression in NIH/3T3 whole cell lysate.
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