NAB1 Background Information Transcriptional control is in part regulated by interactions between DNA-bound transcription factors, such as Egr1/NGFI-A, and coregulatory proteins, such as NAB (for NGFI-A-binding proteins). The evolutionarily conserved NAB proteins, NAB1 and NAB2, are corepressors of Egr1/NGFI-A. Both NAB1 and NAB2 contain an amino-terminal NAB-conserved domain 1 (NCB1), which is required for binding NGFI-A, and a carboxy-terminal NCD2, which is responsible for the repressor function of NAB proteins. NAB1 requires NGFI-A to gain access to DNA, indicating that NAB1 is an active repressor that works by a direct mechanism. NAB1, which is constitutively expressed, is localized exclusively in the nucleus and may play a role in controlling processes such as cell division, differentiation and apoptosis.
NAB1 (2607C2a)
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NAB1 (2607C2a): sc-81565 Western Blot analysis of human recombinant NAB1 fusion protein.
NAB1 (2607C2a): sc-81565. Western blot analysis of NAB1 expression in non-transfected: sc-117752 (A) and mouse NAB1 transfected: sc-121928 (B) 293T whole cell lysates.
NAB1 (2607C2a): sc-81565. Western blot analysis of NAB1 expression in HeLa whole cell lysate.
NAB1 (2607C2a): sc-81565. Western blot analysis of NAB1 expression in non-transfected 293T: sc-117752 (A), human NAB1 transfected 293T: sc-115360 (B) and SK-N-MC (C) whole cell lysates.
