epitope mapping at the N-terminus of SREBP-2 of human origin
recommended for detection of SREBP-2 of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA; also reactive with additional species, including canine
blocking peptide, sc-8151 P
TransCruz reagent for Gel Supershift and ChIP applications, sc-8151 X, 200 µg/0.1 ml
SREBP-2 Background Information The low density lipoprotein (LDL) receptor mediates the endocytic uptake of cholesterol-carrying lipoproteins, thereby controlling cholesterol levels in cells and plasma. Transcription of the LDL receptor gene is controlled by a 10 base pair sequence in the 5' flanking region, designated sterol regulatory element 1 (SRE-1). When cellular sterol stores are depleted, the element is activated, the gene is transcribed and the cellular uptake of LDL increases. A set of SRE-binding proteins (SREBPs) have been identified, including two basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factors, designated SREBP-1 and SREBP-2. SREBP-1 and SREBP-2 have been shown to have the same specificity for SRE-1 in vitro and to activate the transcription of reporter genes containing SRE-1 in the same way.
SREBP-2 (N-19) Product Citations
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SREBP-2 (N-19)
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SREBP-2 (N-19): sc-8151. Western blot analysis of SREBP-2 expression in U-937 (A) and PC-3 (B) nuclear extracts.
SREBP-2 (N-19): sc-8151. Western blot analysis of SREBP-2 expression in non-transfected: sc-117752 (A) and human SREBP-2 transfected: sc-116625 (B) 293T whole cell lysates.
