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p-Neu Antibody (12B9): sc-81505

 |  Datasheet

(Based on data analysis)
  • p-Neu Antibody (12B9) is a mouse monoclonal IgG1 provided at 50 µg/0.5 ml
  • raised against phosphopeptide corresponding to amino acid residues surrounding tyrosine 877 of Neu of human origin
  • recommended for detection of Tyr 877 phosphorylated Neu of human origin by WB
 

See additional Neu Antibodies.

Also see Neu Inhibitors for functional analysis of cellular responses to Neu.


Ordering InformationGene Info
Recommended Support Products:
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WB   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
p-Neu Antibody (12B9) sc-81505 50 µg/0.5 ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Neu siRNA (h) sc-29405 10 µM $258
Neu (h)-PR sc-29405-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Neu shRNA Plasmid (h) sc-29405-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Neu shRNA (h) Lentiviral Particles sc-29405-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
A-431 + EGF Whole Cell Lysate sc-2202 500 µg/200 µl $104
SK-BR-3 Cell Lysate sc-2218 500 µg/200 µl $104
A-431 Whole Cell Lysate sc-2201 500 µg/200 µl $104
MDA-MB-231 Cell Lysate sc-2232 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human ERBB2 2064 17q12 NM_001005862, NM_004448 P04626
 211980
 

Neu (v-ErbB-2 erythroblastic leukemia viral oncogene homolog 2, HER-2, NGL, TKR1, c-ErbB-2) oncogene was originally cloned from a rat neuroglio-blastoma. Human Neu is referred to as HER2 since the protein structure re-sembles human epidermal growth factor receptor (HER). ErbB-2 refers to a high level of similarity to ErbB (avian erythroblastosis oncogene B), later found to code for EGFR (HER). Tyr 1248 phosphorylated Neu localizes with Mucin4/ Sialomucin complex at the apical surfaces of ductal and alveolar cells in rodent lactating gland. Phosphorylation of Neu at Tyr 1139 promotes association of GRB2 and GRB7 through a Src homology 2 (SH2) domain-dependent interaction, and contributes to the etiology of certain breast, gastric and esophageal cancers, and testicular germ cell tumors. Neu phosphorylation on Tyr 1221 and Tyr 1248 promotes association of Shc (SH2 domain-containing transforming protein 1) through an SH2 domain. Neu phosphorylation at Tyr 1196 and Tyr 1248 promotes association of Shc through a PTB (phosphotyrosine binding) domain. SH2 and PTB domains recognize tyrosine phosphorylated proteins in a sequence-specific fashion and transduce extracellular signals via subcellular targeting, directing assembly of complexes and modulating enzymatic activity.