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GSK-3α Antibody (10C1): sc-81463

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  • GSK-3α Antibody (10C1) is a mouse monoclonal IgG1 provided at 50 µg/0.5 ml
  • raised against GSK-3α of human origin
  • recommended for detection of GSK-3α of mouse, rat and human origin by WB and IP; non cross-reactive with GSK-3β; also reactive with additional species, including canine
 

See additional GSK Antibodies including GSK, GSK-3 alpha and GSK-3 beta.

Also see chemical GSK-3 alpha Inhibitors for functional analysis of cellular responses to GSK-3 alpha.


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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
GSK-3α Antibody (10C1) sc-81463 50 µg/0.5 ml $279
 CRISPR KO, HDR and Nickase Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
GSK-3α CRISPR/Cas9 KO Plasmid (h) sc-400518 20 µg $345
GSK-3α HDR Plasmid (h) sc-400518-HDR 20 µg $385
GSK-3α Double Nickase Plasmid (h) sc-400518-NIC 20 µg $355
GSK-3α Double Nickase Plasmid (h2) sc-400518-NIC-2 20 µg $355
GSK-3α CRISPR/Cas9 KO Plasmid (m) sc-436875 20 µg $345
GSK-3α HDR Plasmid (m) sc-436875-HDR 20 µg $385
GSK-3α Double Nickase Plasmid (m) sc-436875-NIC 20 µg $355
GSK-3α Double Nickase Plasmid (m2) sc-436875-NIC-2 20 µg $355
 CRISPR Activation Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
GSK-3α CRISPR Activation Plasmid (h) sc-400518-ACT 20 µg $345
GSK-3α CRISPR Activation Plasmid (h2) sc-400518-ACT-2 20 µg $345
GSK-3α Lentiviral Activation Particles (h) sc-400518-LAC 200 µl $395
GSK-3α Lentiviral Activation Particles (h2) sc-400518-LAC-2 200 µl $395
GSK-3α CRISPR Activation Plasmid (m) sc-436875-ACT 20 µg $345
GSK-3α CRISPR Activation Plasmid (m2) sc-436875-ACT-2 20 µg $345
GSK-3α Lentiviral Activation Particles (m) sc-436875-LAC 200 µl $395
GSK-3α Lentiviral Activation Particles (m2) sc-436875-LAC-2 200 µl $395
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
GSK-3α siRNA (h) sc-29339 10 µM $258
GSK-3α siRNA (m) sc-35526 10 µM $258
GSK-3α siRNA (m2) sc-270018 10 µM $258
GSK-3α (h)-PR sc-29339-PR 10 µM, 20 µl $23
GSK-3α (m)-PR sc-35526-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
GSK-3α shRNA Plasmid (h) sc-29339-SH 20 µg $520
GSK-3α shRNA Plasmid (m) sc-35526-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
GSK-3α shRNA (h) Lentiviral Particles sc-29339-V 200 µl $625
GSK-3α shRNA (m) Lentiviral Particles sc-35526-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
GSK-3α (h): 293T Lysate sc-114699 100 µg/200 µl $205
A549 Cell Lysate sc-2413 500 µg/200 µl $104
SK-BR-3 Cell Lysate sc-2218 500 µg/200 µl $104
Jurkat Whole Cell Lysate sc-2204 500 µg/200 µl $104
HeLa Whole Cell Lysate sc-2200 500 µg/200 µl $104
A549 Cell Lysate sc-2413 500 µg/200 µl $104
rat brain extract sc-2392 500 µg/200 µl $104
A-431 Whole Cell Lysate sc-2201 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human GSK3A 2931 19q13.2 NM_019884 P49840
606784
Mouse Gsk3a 606496 7 A3 Q2NL51
N/A
 


Glycogen synthase kinase 3, or GSK-3, is a serine/threonine, proline-directed kinase involved in a diverse array of signaling pathways, including glycogen synthesis and cellular adhesion, and has been implicated in Alzheimer’s disease. Two forms of GSK-3, designated GSK-3å and GSK-3∫, have been identified and differ in their subcellular localization. Tau, a microtubule-binding protein which serves to stabilize microtubules in growing axons, is found to be hyper-phosphorylated in paired helical filaments (PHF), the major fibrous component of neurofibrillary lesions associated with Alzheimer’s disease. Hyperphosphorylation of Tau is thought to be the critical event leading to the assembly of PHF. Six Tau protein isoforms have been identified, all of which are phosphorylated by GSK-3. This presents the possibility that miscues in GSK-3 signaling contribute to the onset of Alzheimer’s disease.

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GSK-3α Antibody (10C1) Data
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GSK-3α (10C1): sc-81463. Western blot analysis of GSK-3α expression in non-transfected 293T: sc-117752 (A), human GSK-3α transfected 293T: sc-114699 (B) and HeLa (C) whole cell lysates.
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