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GSK-3β Antibody (11B9): sc-81462

 |  Datasheet

(Based on data analysis)

  • GSK-3β Antibody (11B9) is a mouse monoclonal IgG1 provided at 50 µg/0.5 ml
  • raised against the N-terminus of GSK-3β of human origin
  • recommended for detection of GSK-3β of mouse, rat and human origin by WB and IP; also reactive with additional species, including canine
  • See 7 citations for GSK-3β Antibody (11B9)
 

See additional GSK Antibodies including GSK, GSK-3 alpha and GSK-3 beta.

Also see GSK-3 beta Inhibitors or GSK-3 beta Substrates for functional analysis of cellular responses to GSK-3 beta.


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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
GSK-3β Antibody (11B9) sc-81462 50 µg/0.5 ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
GSK-3β siRNA (h) sc-35527 10 µM $258
GSK-3β siRNA (m) sc-35525 10 µM $258
GSK-3β (h)-PR sc-35527-PR 10 µM, 20 µl $23
GSK-3β (m)-PR sc-35525-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
GSK-3β shRNA Plasmid (h) sc-35527-SH 20 µg $520
GSK-3β shRNA Plasmid (m) sc-35525-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
GSK-3β shRNA (h) Lentiviral Particles sc-35527-V 200 µl $625
GSK-3β shRNA (m) Lentiviral Particles sc-35525-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
HeLa Whole Cell Lysate sc-2200 500 µg/200 µl $104
A549 Cell Lysate sc-2413 500 µg/200 µl $104
SK-BR-3 Cell Lysate sc-2218 500 µg/200 µl $104
Jurkat Whole Cell Lysate sc-2204 500 µg/200 µl $104
GSK-3β (m): 293T Lysate sc-120654 100 µg/200 µl $205
3611-RF Whole Cell Lysate sc-2215 500 µg/200 µl $104
A-431 Whole Cell Lysate sc-2201 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human GSK3B 2932 3q13.33 NM_002093 P49841
605004
Mouse Gsk3b 56637 16 B3 Q9WV60
N/A
 


Glycogen synthase kinase 3, or GSK-3, is a serine/threonine, proline-directed kinase involved in a diverse array of signaling pathways, including glycogen synthesis (1) and cellular adhesion (2,3), and has been implicated in Alzheimer’s disease. Two forms of GSK-3, designated GSK-3å and GSK-3∫, have been identified and differ in their subcellular localization (4). Tau, a microtubule-binding protein which serves to stabilize microtubules in growing axons, is found to be hyper-phosphorylated in paired helical filaments (PHF), the major fibrous component of neurofibrillary lesions associated with Alzheimer’s disease (5,6). Hyperphosphorylation of Tau is thought to be the critical event leading to the assembly of PHF (7). Six Tau protein isoforms have been identified, all of which are phosphorylated by GSK-3 (8). This presents the possibility that miscues in GSK-3 signaling contribute to the onset of Alzheimer’s disease.

GSK-3β Antibody (11B9) Product Citations
See how others have used GSK-3β Antibody (11B9) and or GSK-3β Antibody (11B9) conjugates.


7 total citations
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GSK-3β Antibody (11B9) Data
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GSK-3β (11B9): sc-81462. Western blot analysis of GSK-3β expression in non-transfected 293T: sc-117752 (A), mouse GSK-3β transfected 293T: sc-120654 (B) and Jurkat (C) whole cell lysates.
GSK-3β (11B9): sc-81462. Western blot analysis of GSK-3β expression in non-transfected 293T: sc-117752 (A), mouse GSK-3β transfected 293T: sc-120655 (B) and HeLa (C) whole cell lysates.
GSK-3β (11B9): sc-81462. Western blot analysis of GSK-3β expression in A-431 whole cell lysate.
GSK-3β (11B9): sc-81462. Western blot analysis of GSK-3β expression in non-transfected: sc-117752 (A) and human GSK-3β transfected: sc-176265 (B) 293T whole cell lysates.
GSK-3β (11B9): sc-81462. Western blot analysis of GSK-3β expression in non-transfected: sc-117752 (A) and mouse GSK-3β transfected: sc-110362 (B) 293T whole cell lysates.
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