epitope mapping at the N-terminus of Occludin of human origin
recommended for detection of Occludin of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
Occludin Background Information Occludin is an integral membrane protein closely associated with the tight junctions of epithelial and endothelial cells. Occludin is a tetraspan integral membrane protein in epithelial and endothelial tight junction (TJ) structures that can contain two extracellular loops. The protein exists in a variety of phosphorylated forms. Phosphorylation is involved in regulating both the localization and the function of occludin. Expression of occludin is up-regulated by polyunsaturated fatty acids, increasing transendothelial cell resistance and reducing cellular permeability to large molecules. The level of occludin varies greatly depending on tissue; in brain tissue, occludin is highly expressed at cell-cell contact sites. Non-neural tissues show lower expression and discontinuous distribution. Up-regulation of epithelial occludin may play a role in enhancing paracellular permeability and be related to the damage to the tight junction.
Occludin (N-19) Product Citations
See how others have used Occludin (N-19): sc-8145 antibody and or Occludin (N-19) antibody conjugates.
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Occludin (N-19)
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Occludin (N-19): sc-8145. Western blot analysis of Occludin expression in COLO 320DM (A) and ECV304 (B) whole cell lysates.
Occludin (N-19): sc-8145. Western blot analysis of Occludin expression in non-transfected: sc-117752 (A) and human Occludin transfected: sc-114467 (B) 293T whole cell lysates.
