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home » Kinases and Phosphatases » ARK Antibody / ARK Antibodies » ARK-1 (7F12): sc-81441

ARK-1 (7F12) Antibody: sc-81441

  |  Datasheet
  • mouse monoclonal IgG1, 50 µg/0.5 ml
  • raised against the N-terminus of ARK-1 of human origin
  • recommended for detection of ARK-1 of mouse, rat and human origin by WB and IP; also reactive with additional species, including canine
 
Additional ARK Antibodies ...
 
Ordering Information
Recommended Support Products:
(click button of application of choice)
siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human AURKA 6790 20q13.2 NM_003600, NM_198433, NM_198434, NM_198435, NM_198436, NM_198437 O14965
 603072
Mouse Aurka 20878 2 H3 P97477
 N/A
 
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
ARK-1 (7F12) sc-81441 50 µg/0.5 ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
ARK-1 siRNA (h) sc-29731 10 µM $258
ARK-1 siRNA (m) sc-29732 10 µM $258
ARK-1 (h)-PR sc-29731-PR 10 µM $23
ARK-1 (m)-PR sc-29732-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
ARK-1 shRNA Plasmid (h) sc-29731-SH 20 µg $520
ARK-1 shRNA Plasmid (m) sc-29732-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
ARK-1 shRNA (h) Lentiviral Particles sc-29731-V 200 µl $625
ARK-1 shRNA (m) Lentiviral Particles sc-29732-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
HeLa Whole Cell Lysate sc-2200 500 µg/200 µl $104
mouse testis extract sc-2405 500 µg/200 µl $104
ARK-1 (h2): 293T Lysate sc-114547 100µg/200µl $205
BT-20 Cell Lysate sc-2223 500 µg/200 µl $104
ARK-1 (m2): 293T Lysate sc-126439 100µg/200µl $205

ARK-1 Background Information
Aurora related kinase-1 (ARK-1, STK15, Aurora2, Aik1) and -2 (ARK-2, STK12, Aurora1) are centrosome-associated serine/threonine kinases that regulate centrosome separation, bipolar spindle assembly and chromosome segregation during mitosis. ARK-1 and -2 are expressed in the nucleus and localize to distinct portions of mitotic machinery such as the centrosome, spindle poles (ARK-1) and midbody (ARK-2) during mitosis. ARK-1 and -2 transcripts are present at high levels in human thymus and fetal liver. ARK-1 protein has elevated expression in colon carcinoma lines (HT-29, SNU-C2B, COLO 205, SW480, 837 and 948) and accumulates during metaphase in HeLa cells. ARK-2 protein levels are maximal during both S and G2/M phases, whereas ARK-1 protein is degraded after G2/M via the ubiquitin-proteasome pathway. ARK-2 has a unique genetic loci relative to ARK-1, suggesting that these two kinases, with oncogenic potential, have different roles in cell cycle progression.
ARK-1 (7F12)
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sc-81441
ARK-1 (7F12): sc-81441. Western blot analysis of ARK-1 expression in non-transfected 293T: sc-117752 (A), mouse ARK-1 transfected 293T: sc-126438 (B) and NTERA-2 cl.D1 (C) whole cell lysates.
sc-81441
ARK-1 (7F12): sc-81441. Western blot analysis of ARK-1 expression in HeLa whole cell lysate.
sc-81441
ARK-1 (7F12): sc-81441. Western blot analysis of ARK-1 expression in HeLa whole cell lysate.
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