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- goat polyclonal IgG, 200 µg/ml
- epitope mapping at the N-terminus of HDAC3 of human origin
- recommended for detection of HDAC3 of human and Drosophila origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
- blocking peptide, sc-8138 P
- TransCruz reagent for ChIP application, sc-8138 X, 200 µg/0.1 ml
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Ordering InformationProduct Citations
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
HDAC3 |
8841 |
5q31.3 |
NM_003883 |
O15379
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605166 |
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HDAC3 Background Information
In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino-terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP and the TFIID subunit TAF II p250. Mammalian HDAC1 (also designated HD1), HDAC2 (also designated RPD3) and HDAC3, all of which are related to the yeast transcriptional factor Rpd3p, have been identified as histone deacetylases.
| HDAC3 (N-19) Product Citations |
See how others have used HDAC3 (N-19): sc-8138 antibody and or HDAC3 (N-19) antibody conjugates.
18 total citations Loading citations.
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HDAC3 (N-19)
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HDAC3 (N-19): sc-8138. Western blot analysis of HDAC3 expression in HeLa (A) and C32 (B) nuclear extracts.
ChIP analysis of cofactor occupancy dynamics on the KAI1 promoter in 293 cells in response to IL-1β treatment. Antibodies tested include NFκB p50 (C-19): sc-1190, NFκB p50 (E-10): sc-8414, NFκB p50 (H-119): sc-7178, NFκB p65 (C-20): sc-372, NFκB p65 (A): sc-109, NFκB p65 (H-286): sc-7151, HDAC3 (H-99): sc-11417, HDAC3 (N-19): sc-8138, Bcl-3 (C-14): sc-185, Bcl-3 (H-146): sc-13038. Data kindly provided by M.G. Rosenfeld and reproduced with permission from Baek et al., Cell 2002, 110: 55-67. HDAC3 (N-19): sc-8138. Western blot analysis of HDAC3 expression in U-87 MG (A) and C6 (B) whole cell lysates.
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