Pax-8 Antibody (PAX8R1): sc-81353

Pax-8 Antibody (PAX8R1) is a mouse monoclonal IgG1 kappa light chain antibody that detects Pax-8 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Anti-Pax-8 antibody (PAX8R1) is available in a non-conjugated form, specifically designed for researchers seeking to study Pax-8 in various biological processes. Pax-8 is a crucial transcription factor that plays a significant role in embryogenesis and differentiation of thyroid follicular cells, vital for proper thyroid hormone biosynthesis. Pax-8 is predominantly expressed in developing and adult thyroid, developing secretory system and, to a lesser extent, adult kidney. Pax-8 interacts with other transcription factors, such as TTF-1 and TTF-2, to regulate expression of key genes involved in thyroid function, including sodium iodide symporter (NIS), thyroid peroxidase (TPO), thyroglobulin (TG), and thyrotropin receptor (TSHR). Mutations in Pax-8 can lead to thyroid dysgenesis, highlighting its importance in thyroid development and function. Pax-8 is located on human chromosome 2q12-q14 and produces six isoforms (A to F) through alternative splicing, which exhibit distinct DNA binding capacities and functional roles, further emphasizing the complexity and significance of Pax-8 in endocrine regulation.

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Pax-8 Antibody (PAX8R1) References:

1. Thyroglobulin regulates follicular function and heterogeneity by suppressing thyroid-specific gene expression.  |  Suzuki, K., et al. 1999. Biochimie. 81: 329-40. PMID: 10401666
2. Congenital hypothyroidism: etiologies, diagnosis, and management.  |  LaFranchi, S. 1999. Thyroid. 9: 735-40. PMID: 10447022
3. Molecular pathogenesis of neonatal hypothyroidism.  |  Krude, H., et al. 2000. Horm Res. 53 Suppl 1: 12-8. PMID: 10895037
4. A unique combination of transcription factors controls differentiation of thyroid cells.  |  Damante, G., et al. 2001. Prog Nucleic Acid Res Mol Biol. 66: 307-56. PMID: 11051768
5. Pax-8 is essential for regulation of the thyroglobulin gene by transforming growth factor-beta1.  |  Kang, HC., et al. 2001. Endocrinology. 142: 267-75. PMID: 11145590
6. PAX-8 expression in renal tumours and distant sites: a useful marker of primary and metastatic renal cell carcinoma?  |  Barr, ML., et al. 2015. J Clin Pathol. 68: 12-7. PMID: 25315900
7. Pax-8: Molecular biology, pathophysiology, and potential pathogenesis.  |  Zhou, Q., et al. 2024. Biofactors. 50: 408-421. PMID: 37988248
8. Prognostic value of PAX8 in small cell lung cancer.  |  Tao, F., et al. 2024. Heliyon. 10: e28251. PMID: 38596099
9. Distinct functional properties of three human paired-box-protein, PAX8, isoforms generated by alternative splicing in thyroid, kidney and Wilms' tumors.  |  Poleev, A., et al. 1995. Eur J Biochem. 228: 899-911. PMID: 7737192
10. Transcription factors and apoptosis in kidney development.  |  Igarashi, P. 1994. Curr Opin Nephrol Hypertens. 3: 308-17. PMID: 7922258
11. Chromosomal localization of seven PAX genes and cloning of a novel family member, PAX-9.  |  Stapleton, P., et al. 1993. Nat Genet. 3: 292-8. PMID: 7981748
12. Pax genes and organogenesis: Pax9 meets tooth development.  |  Peters, H., et al. 1998. Eur J Oral Sci. 106 Suppl 1: 38-43. PMID: 9541201

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Pax-8 Antibody (PAX8R1) has 15 citations in a variety of scientific publications.

Primary antibodies like Anti-Pax-8 Antibody (PAX8R1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Pax-8 Antibody (PAX8R1) Specifications

Alternate Product Name: Pax-8

Product Clone Name: PAX8R1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: Pax-8

Epitope Species: human

Product Reactivity/Detection: Pax-8 A and Pax-8 B

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 15 citations in various scientific publications

Available Conjugates/Forms for Pax-8 Antibody (PAX8R1): N/A

The preferred Pax-2/5/8 antibody is Pax-2/5/8 Antibody (G-3): sc-377181.