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Nur77 Antibody (NR4AB9G12): sc-81344

 |  Datasheet

(Based on data analysis)

  • Nur77 Antibody (NR4AB9G12) is a mouse monoclonal IgG1 provided at 100 µg/ml
  • raised against a recombinant protein corresponding to an internal region of Nur77 of human origin
  • recommended for detection of Nur77 of human origin by WB and IP
 

See additional Nur Antibodies.

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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
Nur77 Antibody (NR4AB9G12) sc-81344 100 µg/ml $295
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Nur77 siRNA (h) sc-36109 10 µM $258
Nur77 siRNA (h2) sc-156146 10 µM $258
Nur77 (h)-PR sc-36109-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Nur77 shRNA Plasmid (h) sc-36109-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Nur77 shRNA (h) Lentiviral Particles sc-36109-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Hep G2 Cell Lysate sc-2227 500 µg/200 µl $104
U-937 nuclear extract sc-2156 250 µg/0.05 ml $143
Jurkat nuclear extract sc-2132 250 µg/0.05 ml $143
U-937 Cell Lysate sc-2239 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human NR4A1 3164 12q13.13 NM_002135, NM_173157, NM_173158 P22736
 139139
 

Nurr1 (Nur-related factor 1) and Nur77 (also designated NGFI-B) encode orphan nuclear receptors which may comprise an additional subfamily within the nuclear receptor superfamily. The rat and human homologs of mouse Nurr1 are designated RNR1 and NOT, respectively. Both Nurr1 and Nur77 are growth factor inducible immediate early response genes. Induction of both Nurr1 and Nur77 is seen after membrane depolarization while only Nur77 induction is seen with NGF stimulation. JunD acts as a mediator for Nur77. An increase in Nur77 expression is seen in activated T cells during G0 to G1 transition and throughout the G1 phase. In addition to its function as an immediate early gene, Nur77 may play a role in TCR-mediated apoptosis. Cyclosporin A, a potent immunosuppressant, has been shown to inhibit the ability of Nur77 to bind DNA. A dominant negative form of Nur77 can protect T cell hybridomas from activation-induced apoptosis. However, the absolute requirement of Nur77 for TCR-mediated apoptosis is still under debate.
Nur77 Antibody (NR4AB9G12) Data
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sc-81344
Nur77 (NR4AB9G12): sc-81344. Western blot analysis of Nur77 expression in non-transfected: sc-117752 (A) and human Nur77 transfected: sc-110000 (B) 293T whole cell lysates.
sc-81344
Nur77 (NR4AB9G12): sc-81344 Western Blot analysis of human recombinant Nur77 fusion protein.
sc-81344
Nur77 (NR4AB9G12): sc-81344. Western blot analysis of Nur77 expression in non-transfected: sc-110760 (A) and human Nur77 transfected: sc-112240 (B) 293 whole cell lysates.
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