FBL4 Background Information
FBL4 is a 621 amino acid protein encoded by the human gene FBXL4. FBL4 contains one 40 amino acid F-box region, making it a member of the F-box family. FBL4 also contains eight LRR (leucine-rich) repeats. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. F-box proteins are members of a large family that regulates cell cycle, immune response, signaling cascades and developmental programs by targeting proteins, such as cyclins, cyclin-dependent kinase inhibitors, IkB-a and b-catenin, for degradation by the proteasome after ubiquitination. Localized near the nucleus in the cytoplasm, FBL4 is expressed in heart, kidney, liver, lung, pancreas, and placenta, however, it is not found in skeletal muscle.
