CDKN2A/p16 Antibody (1E12E10): sc-81156
- CDKN2A/p16 Antibody (1E12E10) is a mouse monoclonal IgG1, cited in 14 publications, provided at 200 µg/ml
- raised against purified truncated recombinant p16 INK4A of human origin
- recommended for detection of p16 INK4A of mouse, rat and human origin by WB, IP, IF and IHC(P)
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CDKN2A/p16 Antibody (1E12E10) for WB and IHC(P) applications. These reagents are now offered in bundles with CDKN2A/p16 Antibody (1E12E10) (see ordering information below).
p16 INK4A Antibody (1E12E10) is a mouse monoclonal IgG1 antibody that detects p16 INK4A in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. p16 INK4A plays a crucial role as a negative regulator of the cell cycle, specifically inhibiting cyclin-dependent kinase 4 (Cdk4) activity, which is essential for the transition from the G1 phase to the S phase of the cell cycle. This regulation is particularly important because dysregulation of p16 INK4A can lead to uncontrolled cell proliferation, a hallmark of cancer. Notably, the gene encoding p16 INK4A is frequently subject to homozygous deletions and point mutations in various human tumor cell lines, highlighting p16 INK4A′s significance as a tumor suppressor. Anti-p16 INK4A antibody (1E12E10) serves as an invaluable tool for researchers studying cell cycle regulation and molecular mechanisms underlying tumorigenesis, providing insights into pathways that may be targeted for therapeutic intervention.
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CDKN2A/p16 Antibody (1E12E10) | sc-81156 | 200 µg/ml | $316.00 | |||
CDKN2A/p16INK4a Antibody (1E12E10): m-IgG Fc BP-HRP Bundle | sc-537240 | 200 µg Ab; 10 µg BP | $354.00 | |||
CDKN2A/p16INK4a Antibody (1E12E10): m-IgGκ BP-HRP Bundle | sc-534460 | 200 µg Ab; 40 µg BP | $354.00 |