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demethylated-PP2A-C Antibody (4i57): sc-80990

 |  Datasheet

(Based on data analysis)

  • demethylated-PP2A-C Antibody (4i57) is a mouse monoclonal IgG1 provided at 100 µg/ml
  • raised against the unmethylated C-terminal region of the PP2A-C subunit
  • recommended for detection of demethylated PP2A-C of mouse, human, Drosophila and Xenopus origin by WB, IP and IHC(P) ; to demethylate, treat with 100mM NaOH on ice
 

See additional PP2 Antibodies including PP2, PP2A-B55-β , PP2A-B55-δ, PP2A-Cβ, PP2Comega, PP2A-A alpha, PP2A-A alpha / beta, PP2A-C , PP2A-C alpha, PP2A-C alpha / beta, PP2B-A, PP2B-A alpha, PP2B-A beta, PP2B-A gamma, PP2C alpha, PP2C alpha / beta, PP2C beta, PP2C epsilon, PP2C eta, PP2C gamma, PP2C kappa, PP2C zeta, PP2B-B1, PP2B-B2, PP2A-B55, PP2A-B55-alpha, PP2A-B55-gamma, PP2A-B56-alpha, PP2A-B56-beta, PP2A-B56-delta, PP2A-B56-gamma, PP2A-B72 and PP2A-B130.

Also see PP2A-C Inhibitors for functional analysis of cellular responses to PP2A-C .


Ordering InformationGene Info
Recommended Support Products:
(click button of application of choice)
WB   IP   IHC(P)   siRNA  
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
demethylated-PP2A-C Antibody (4i57) sc-80990 100 µg/ml $279
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
MCF7 Whole Cell Lysate sc-2206 500 µg/200 µl $104
NIH/3T3 Whole Cell Lysate sc-2210 500 µg/200 µl $104
KNRK Whole Cell Lysate sc-2214 500 µg/200 µl $104
A-431 Whole Cell Lysate sc-2201 500 µg/200 µl $104
K-562 Whole Cell Lysate sc-2203 500 µg/200 µl $104
PP2A-Cβ (h): 293T Lysate sc-113470 100 µg/200 µl $205
Hep G2 Cell Lysate sc-2227 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human PPP2CB 5516 8p12 NM_001009552, NM_004156 P62714
176916
Mouse Ppp2cb 19053 8 A4 P62715
N/A
 


In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions, including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases. In general, the protein phosphatase (PP) holoenzyme is a trimeric complex composed of a regulatory subunit, a variable subunit, and a catalytic subunit. Four major families of protein phosphatase catalytic subunits have been identified, designated PP1, PP2A, PP2B (calcineurin) and PP2C. An additional protein phosphatase catalytic subunit, PPX (also known as PP4) is a putative member of a novel PP family. The PP2A catalytic subunit is a protein that associates with a variety of regulatory subunits. Regulatory subunits include PP2A-Aa and -Ab, PP2A-Ba and -Bb, PP2A-Ca and -Cb, PP2A-B56a and -B56b.

demethylated-PP2A-C Antibody (4i57) Data
Click on image to enlarge
demethylated-PP2A-C (4i57): sc-80990. Immunoperoxi-dase staining of formalin fixed, paraffin-embedded human duodenum tissue showing cytoplasmic staining of glandular cells.
demethylated-PP2A-C (4i57): sc-80990. Western blot analysis of demethylated-PP2A-C expression in KNRK (A) and A-431 (B) whole cell lysates.
demethylated-PP2A-C (4i57): sc-80990. Western blot analysis of demethylated-PP2A-Cβ expression in non-transfected: sc-117752 (A) and human PP2A-Cβ transfected: sc-113470 (B) 293T whole cell lysates.
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