Angiotensin I (BGN/KA/22H) Antibody: sc-80682

Angiotensin I Background Information
Angiotensin is formed from a precursor, angiotensinogen, which is produced by the liver and found in the a-globulin fraction of plasma. The lowering of blood pressure is a stimulus to secretion of renin by the kidney into the blood. Renin cleaves, from Angiotensinogen, a terminal decapeptide, Angiotensin I (Ang I). This is further altered by the Angiotensin-converting enzyme (ACE) that enzymatically removes a dipeptide to form Angiotensin II (Ang II). Angiotensin II, an octapeptide hormone, is an important physiological effector of blood pressure and volume regulation through vasoconstriction, aldosterone release, sodium uptake and thirst stimulation. It has been shown that mechanical stress causes release of Angiotensin II from cardiac myocytes and that Angiotensin II acts as an initial mediator of the hypertrophic response. Angiotensin II treatment also stimulates phosphorylation of Shc, FAK and MAP kinases and induces MKP-1, indicating stimulation of growth factor pathways.